ArrayExpress Uploader06002Villin-CRE+ (PPAR g null epithelial cell)0Villin-CRE+ (PPAR g null epithelial cell)0Villin-CRE+ (PPAR g null epithelial cell)0Villin-CRE+ (PPAR g null epithelial cell)2Villin-CRE+ (PPAR g null epithelial cell)2Villin-CRE+ (PPAR g null epithelial cell)2Villin-CRE+ (PPAR g null epithelial cell)2Villin-CRE+ (PPAR g null epithelial cell)2Villin-CRE+ (PPAR g null epithelial cell)7Villin-CRE+ (PPAR g null epithelial cell)7Villin-CRE+ (PPAR g null epithelial cell)7Villin-CRE+ (PPAR g null epithelial cell)7Villin-CRE- (Wild-type epithelial cell)0Villin-CRE- (Wild-type epithelial cell)0Villin-CRE- (Wild-type epithelial cell)0Villin-CRE- (Wild-type epithelial cell)2Villin-CRE- (Wild-type epithelial cell)2Villin-CRE- (Wild-type epithelial cell)2Villin-CRE- (Wild-type epithelial cell)7Villin-CRE- (Wild-type epithelial cell)7Villin-CRE- (Wild-type epithelial cell)7Villin-CRE- (Wild-type epithelial cell)7arrayexpress_sid6BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate...20422041E-GEOD-20621/profile/8773/arrayexpressuploader222bodycellcolitiscolondiseasedssepithelial celllymphmacrophagemucosaperoxisomeDec.12, 2014Falsetranscription-profiling-by-array-of-mus-musculus-cE-GEOD-20621_A-AFFY-45Transcription profiling by array of Mus musculus colonic mucosa after treatment with DSSNov.11, 2014BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion of PPAR g in epithelial cells modulates the severity of dextran-sodium sulfate (DSS)-induced colitis, immune cell distribution and global gene expression. RESULTS: The deficiency of PPAR g in epithelial cells does not significantly affect disease activity or body weight but worsens colon histopathlogy. WT mice have greater CD4+IL10+ T cells and fewer MHC II+ macrophages in mesenteric lymph nodes. Global gene expression analysis reveals greater changes after 7 days of DSS challenge (compared to 2 days). Colonic mucosa from VC- (WT) and VC+ (PPARg knock-out in epithelial cells) mice were sampled at 0 (no DSS), 2, and 7 days of DSS-induced experimental colitishttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20621mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20621/samples/