Dataset: Blood Gene Expression Signatures Predict Invasive Candidiasis
Focusing on host response to infection, we utilized a murine model to develop a blood gene expression signature that accurately...
Focusing on host response to infection, we utilized a murine model to develop a blood gene expression signature that accurately classified mice with candidemia and distinguished candidemia from S. aureus bacteremia. Validation of the signature was achieved in an independent cohort of mice. BALB/c male mice were injected with either normal saline, C.albicans, or S.aureus and sacrificed at pre-set time points of 24, 48, 72-96 hrs (Infection Duration). Blood was placed in RNA Later (R) for RNA expression analysis and the right kidney collected for analysis of pathogen burden.
- Species:
- mouse
- Samples:
- 72
- Source:
- E-GEOD-20524
- Updated:
- Dec.12, 2014
- Registered:
- Nov.24, 2014
Factors:
(via ArrayExpress)
| Sample | COHORT | INFECTION STATUS | INFECTION DURATION (DAYS) |
|---|---|---|---|
| GSM515522 | C.albicans Initial Signature Cohort | healthy | 1 |
| GSM515522 | C.albicans Initial Signature Cohort | healthy | 1 |
| GSM515522 | C.albicans Initial Signature Cohort | healthy | 1 |
| GSM515522 | C.albicans Initial Signature Cohort | healthy | 1 |
| GSM515526 | C.albicans Initial Signature Cohort | healthy | 4 |
| GSM515527 | C.albicans Initial Signature Cohort | candida | 1 |
| GSM515527 | C.albicans Initial Signature Cohort | candida | 1 |
| GSM515527 | C.albicans Initial Signature Cohort | candida | 1 |
| GSM515527 | C.albicans Initial Signature Cohort | candida | 1 |
| GSM515527 | C.albicans Initial Signature Cohort | candida | 1 |
| GSM515527 | C.albicans Initial Signature Cohort | candida | 1 |
| GSM515527 | C.albicans Initial Signature Cohort | candida | 1 |
| GSM515527 | C.albicans Initial Signature Cohort | candida | 1 |
| GSM515535 | C.albicans Initial Signature Cohort | candida | 4 |
| GSM515536 | C.albicans Initial Signature Cohort | candida | 2 |
| GSM515536 | C.albicans Initial Signature Cohort | candida | 2 |
| GSM515536 | C.albicans Initial Signature Cohort | candida | 2 |
| GSM515536 | C.albicans Initial Signature Cohort | candida | 2 |
| GSM515536 | C.albicans Initial Signature Cohort | candida | 2 |
| GSM515536 | C.albicans Initial Signature Cohort | candida | 2 |
| GSM515542 | C.albicans Initial Signature Cohort | candida | 3 |
| GSM515542 | C.albicans Initial Signature Cohort | candida | 3 |
| GSM515542 | C.albicans Initial Signature Cohort | candida | 3 |
| GSM515542 | C.albicans Initial Signature Cohort | candida | 3 |
| GSM515542 | C.albicans Initial Signature Cohort | candida | 3 |
| GSM515542 | C.albicans Initial Signature Cohort | candida | 3 |
| GSM515542 | C.albicans Initial Signature Cohort | candida | 3 |
| GSM515535 | C.albicans Initial Signature Cohort | candida | 4 |
| GSM515535 | C.albicans Initial Signature Cohort | candida | 4 |
| GSM515535 | C.albicans Initial Signature Cohort | candida | 4 |
| GSM515535 | C.albicans Initial Signature Cohort | candida | 4 |
| GSM515535 | C.albicans Initial Signature Cohort | candida | 4 |
| GSM515535 | C.albicans Initial Signature Cohort | candida | 4 |
| GSM515522 | C.albicans Initial Signature Cohort | healthy | 1 |
| GSM515522 | C.albicans Initial Signature Cohort | healthy | 1 |
| GSM515522 | C.albicans Initial Signature Cohort | healthy | 1 |
| GSM515522 | C.albicans Initial Signature Cohort | healthy | 1 |
| GSM515526 | C.albicans Initial Signature Cohort | healthy | 4 |
| GSM515526 | C.albicans Initial Signature Cohort | healthy | 4 |
| GSM515526 | C.albicans Initial Signature Cohort | healthy | 4 |
| GSM515562 | C.albicans Signature Validation Cohort | candida | 1 |
| GSM515562 | C.albicans Signature Validation Cohort | candida | 1 |
| GSM515562 | C.albicans Signature Validation Cohort | candida | 1 |
| GSM515562 | C.albicans Signature Validation Cohort | candida | 1 |
| GSM515562 | C.albicans Signature Validation Cohort | candida | 1 |
| GSM515562 | C.albicans Signature Validation Cohort | candida | 1 |
| GSM515568 | C.albicans Signature Validation Cohort | candida | 2 |
| GSM515568 | C.albicans Signature Validation Cohort | candida | 2 |
| GSM515568 | C.albicans Signature Validation Cohort | candida | 2 |
| GSM515568 | C.albicans Signature Validation Cohort | candida | 2 |
| GSM515568 | C.albicans Signature Validation Cohort | candida | 2 |
| GSM515568 | C.albicans Signature Validation Cohort | candida | 2 |
| GSM515568 | C.albicans Signature Validation Cohort | candida | 2 |
| GSM515568 | C.albicans Signature Validation Cohort | candida | 2 |
| GSM515576 | C.albicans Signature Validation Cohort | candida | 3 |
| GSM515576 | C.albicans Signature Validation Cohort | candida | 3 |
| GSM515576 | C.albicans Signature Validation Cohort | candida | 3 |
| GSM515576 | C.albicans Signature Validation Cohort | candida | 3 |
| GSM515580 | C.albicans Signature Validation Cohort | healthy | 1 |
| GSM515580 | C.albicans Signature Validation Cohort | healthy | 1 |
| GSM515582 | S. aureus Exposure Cohort | staph | 2 |
| GSM515583 | S. aureus Exposure Cohort | staph | 1 |
| GSM515583 | S. aureus Exposure Cohort | staph | 1 |
| GSM515582 | S. aureus Exposure Cohort | staph | 2 |
| GSM515582 | S. aureus Exposure Cohort | staph | 2 |
| GSM515582 | S. aureus Exposure Cohort | staph | 2 |
| GSM515582 | S. aureus Exposure Cohort | staph | 2 |
| GSM515589 | S. aureus Exposure Cohort | staph | 3 |
| GSM515589 | S. aureus Exposure Cohort | staph | 3 |
| GSM51559 | S. aureus Exposure Cohort | healthy | 1 |
| GSM51559 | S. aureus Exposure Cohort | healthy | 1 |
| GSM51559 | S. aureus Exposure Cohort | healthy | 1 |