{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM243346 1": {}}, {"GSM243347 1": {}}, {"GSM243348 1": {}}, {"GSM509260 1": {}}, {"GSM509261 1": {}}, {"GSM509262 1": {}}], "id": 5976, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "We define a pathogenic role for a \u00df-catenin-activated genetic pathway in murine renal dysplasia. Cre-mediated stabilization of \u00df-catenin...", "pubmed_id": 21436291, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 6, "tags": ["cancer", "cell", "exon", "genome", "kidney", "renal aplasia"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-20325_A-AFFY-45", "slug": "stabilization-of-catenin-during-murine-kidney-deve", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20325", "geo_gds_id": "", "name": "Stabilization of \u00df-catenin during murine Kidney Development", "created": "Nov.11, 2014", "summary": "We define a pathogenic role for a \u00df-catenin-activated genetic pathway in murine renal dysplasia. Cre-mediated stabilization of \u00df-catenin in the ureteric cell lineage prior to the onset of kidney development increased \u00df-catenin levels and caused renal aplasia or severe hypodysplasia. A genome-wide analysis of mRNA expression in dysplastic tissue identified down-regulation of genes required for ureteric branching and up regulation of Tgf\u00df2 and Dkk1.  Hoxb7-Cre:EGFP mice ( Zhao, et al. (2004) Dev Biol 276:403-415) were crossed with mice containing loxP sites flanking exon 3 of the \u00df-catenin allele (\u00df-catdelta3/delta3) (Harada,et al. (2002) Cancer Res 62:1971-1977) to generate \u00df-catenin gain-of-function mutant mice specific to the uteric bud, termed \u00df-catGOF-UB .Eighteen \u00df-catGOF-UB mutant kidneys and 9 WT kidneys were micro-dissected at E12.5. Mutant kidneys were divided into three random pools (n=3) consisting of 6 kidneys each and mRNA expression assessed by microarray.", "geo_gse_id": "E-GEOD-20325", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20325/samples/"}