ArrayExpress Uploaderarrayexpress_sidhumannone LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202none LMP-4202357504[original title] LMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells and...20613784E-GEOD-20211/profile/8773/arrayexpressuploader226chronic lymphocytic leukemialeukemiapurineDec.12, 2014Falsetranscription-profiling-by-array-of-human-chroni-2E-GEOD-20211_A-AFFY-44Transcription profiling by array of human chronic lymphocytic leukemia cells after treatment with LMP-420Sep.15, 2014[original title] LMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells and minimal toxicity for normal hematopoietic cells. LMP-420 induces cytotoxicity and apoptosis to CLL cells in vitro without any negative effects to normal immune cells. This gene expression experiment compares CLL cells treated with LMP-420 versus media alone to investigate the mechanism of action of LMP-420. CLL cells from 13 patients were treated with LMP-420 or media for 24 hours, then RNA was extracted and assayed on U133Plus2 GeneChips.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20211http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20211/samples/