ArrayExpress Uploader0mousewild_typewild_typewild_typewild_typewild_typewild_typeHDAC1 KOHDAC1 KOHDAC1 KOHDAC2 KdHDAC2 KdHDAC2 KdHDAC1 KO/HDAC2 KdHDAC1 KO/HDAC2 KdHDAC1 KO/HDAC2 Kd5967arrayexpress_sid6Previously published data suggested some redundant functions between HDAC1 and HDAC2 in mouse. To test this hypothesis, we used...E-GEOD-20100/profile/8773/arrayexpressuploader115genomeDec.12, 2014Falseexpression-data-from-primary-mef-lacking-either-hdE-GEOD-20100_A-AFFY-45Expression data from primary MEF lacking either HDAC1, HDAC2 or bothNov.11, 2014Previously published data suggested some redundant functions between HDAC1 and HDAC2 in mouse. To test this hypothesis, we used microarrays to have a genome wide analysis at the transcription level of primary MEFs lacking HDAC1, HDAC2. MEF HDAC1 F/F were were transduced with two different retroviruses: one virus expresses the Tamoxifen-inducible cre recombinase Cre-ERT2 and the second virus expresses either a small hairpin micro-RNA against HDAC2 or a scrambled version. HDAC1F/F MEFs expressing either a scrambled micro-RNA or a micro-RNA against HDAC2 can be induced by addition of Tamoxifen to delete HDAC1, thereby generating four different genotypes: WT, HDAC1 KO, HDAC2 knockdown (Kd) and HDAC1/2 KO/Kd.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20100http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20100/samples/