{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM502333": {"GENOTYPE": "wild_type"}}, {"GSM502333": {"GENOTYPE": "wild_type"}}, {"GSM502333": {"GENOTYPE": "wild_type"}}, {"GSM502333": {"GENOTYPE": "wild_type"}}, {"GSM502333": {"GENOTYPE": "wild_type"}}, {"GSM502333": {"GENOTYPE": "wild_type"}}, {"GSM502339": {"GENOTYPE": "HDAC1 KO"}}, {"GSM502339": {"GENOTYPE": "HDAC1 KO"}}, {"GSM502339": {"GENOTYPE": "HDAC1 KO"}}, {"GSM502342": {"GENOTYPE": "HDAC2 Kd"}}, {"GSM502342": {"GENOTYPE": "HDAC2 Kd"}}, {"GSM502342": {"GENOTYPE": "HDAC2 Kd"}}, {"GSM502345": {"GENOTYPE": "HDAC1 KO/HDAC2 Kd"}}, {"GSM502345": {"GENOTYPE": "HDAC1 KO/HDAC2 Kd"}}, {"GSM502345": {"GENOTYPE": "HDAC1 KO/HDAC2 Kd"}}], "id": 5967, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Previously published data suggested some redundant functions between HDAC1 and HDAC2 in mouse. To test this hypothesis, we used...", "geo_gse_id": "E-GEOD-20100", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 15, "tags": ["genome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-primary-mef-lacking-either-hd", "geo_id_plat": "E-GEOD-20100_A-AFFY-45", "name": "Expression data from primary MEF lacking either HDAC1, HDAC2 or both", "created": "Nov.11, 2014", "summary": "Previously published data suggested some redundant functions between HDAC1 and HDAC2 in mouse. To test this hypothesis, we used microarrays to have a genome wide analysis at the transcription level of primary MEFs lacking HDAC1, HDAC2. MEF HDAC1 F/F were were transduced with two different retroviruses: one virus expresses the Tamoxifen-inducible cre recombinase Cre-ERT2 and the second virus expresses either a small hairpin micro-RNA against HDAC2 or a scrambled version. HDAC1F/F MEFs expressing either a scrambled micro-RNA or a micro-RNA against HDAC2 can be induced by addition of Tamoxifen to delete HDAC1, thereby generating four different genotypes: WT, HDAC1 KO, HDAC2 knockdown (Kd) and HDAC1/2 KO/Kd.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20100", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20100/samples/"}