ArrayExpress Uploaderarrayexpress_sidmousep27delta51wild type596506Low levels of the cell cycle regulator p27Kip1 are associated with a worse outcome in many tumor types. We report here a new regulatory...E-GEOD-20064/profile/8773/arrayexpressuploader12cellDec.12, 2014FalseE-GEOD-20064_A-AFFY-45expression-data-from-p27delta51-mefs-cells-in-quieExpression data from p27delta51 MEFs cells in quiescenceNov.11, 2014Low levels of the cell cycle regulator p27Kip1 are associated with a worse outcome in many tumor types. We report here a new regulatory role of p27Kip1 as a transcriptional regulator. In association with transcriptional repressors such as p130, E2F4 and HDACs, p27 binds to promoters of multiple genes leading to their repression. The p27Kip1-target genes participate in RNA processing, translation, respiration and cell cycle. Remarkably, p27Kip1-target genes are over-expressed in different human tumors in tight association with a poor clinical prognosis. We also observed a clear correlation between low levels of p27Kip1 and over-expression of p27Kip1-target genes in tumors. Overall, our findings indicate new tumor suppressor roles of p27Kip1 as a transcriptional regulator of genes relevant for oncogenesis. Samples from MEFs p27delta51 and p27WT cells used as control were analyzedhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20064http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20064/samples/