{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM501474": {"VARIATION": "p27delta51"}}, {"GSM501475": {"VARIATION": "wild type"}}], "id": 5965, "pop_total": 0, "platform": 6, "summary_wrapped": "Low levels of the cell cycle regulator p27Kip1 are associated with a worse outcome in many tumor types. We report here a new regulatory...", "geo_gse_id": "E-GEOD-20064", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 2, "tags": ["cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-20064_A-AFFY-45", "slug": "expression-data-from-p27delta51-mefs-cells-in-quie", "geo_gds_id": "", "name": "Expression data from p27delta51 MEFs cells in quiescence", "created": "Nov.11, 2014", "summary": "Low levels of the cell cycle regulator p27Kip1 are associated with a worse outcome in many tumor types. We report here a new regulatory role of p27Kip1 as a transcriptional regulator. In association with transcriptional repressors such as p130, E2F4 and HDACs, p27 binds to promoters of multiple genes leading to their repression. The p27Kip1-target genes participate in RNA processing, translation, respiration and cell cycle. Remarkably, p27Kip1-target genes are over-expressed in different human tumors in tight association with a poor clinical prognosis. We also observed a clear correlation between low levels of p27Kip1 and over-expression of p27Kip1-target genes in tumors. Overall, our findings indicate new tumor suppressor roles of p27Kip1 as a transcriptional regulator of genes relevant for oncogenesis. Samples from MEFs p27delta51 and p27WT cells used as control were analyzed", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20064", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20064/samples/"}