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Home › Dataset Library › Transcription profiling by array of human chromophobe renal cell carcinoma and oncocytoma samples

Dataset: Transcription profiling by array of human chromophobe renal cell carcinoma and oncocytoma samples

[original title] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and...

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[original title] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. Background : Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are two distinct but closely related entities with strong morphologic and genetic similarities. While chRCC is a malignant tumor, oncocytoma is usually regarded as a benign entity. The overlapping characteristics are best explained by a common cellular origin, and the biologic differences between chRCC and oncocytoma are therefore of considerable interest in terms of carcinogenesis, diagnosis and clinical management. Previous studies have been relatively limited in terms of examining the differences between oncocytoma and chromophobe RCC. Methods : Gene expression profiling using the Affymetrix HGU133Plus2 platform was applied on chRCC (n=15) and oncocytoma specimens (n=15). Supervised analysis was applied to identify a discriminatory gene signature, as well as differentially expressed genes. Immunohistochemical validation was performed in an independent set of tumors. Results : A novel 14 probe-set signature was developed to classify the tumors internally with 93% accuracy, and this was successfully validated on an external data-set with 94% accuracy. Parafibromin, aquaporin 6, and synaptogyrin 3 were novel immunohistochemical markers effectively discriminating the two pathologic entities. Conclusion : Gene expression profiles and pathway analysis effectively distinguish chRCC from oncocytoma. We have generated a novel transcript predictor that is able to discriminate between the two entities accurately, and which has been validated both in an internal and an independent data-set, implying generalizability. We have identified a series of immunohistochemical markers that are clinically useful in discriminating chRCC and oncocytoma. 30 mRNA profiling samples (15 chromophobe RCC, 15 oncocytoma)

Species:
human

Samples:
30

Source:
E-GEOD-19982

PubMed:
20462447

Updated:
Dec.12, 2014

Registered:
Sep.15, 2014


Factors: (via ArrayExpress)
Sample disease state
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499330 chromophobe renal cell carcinoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma
GSM499345 renal oncocytoma

Tags

  • aquaporin
  • carcinoma
  • cell
  • chromophobe renal cell carcinoma
  • external
  • internal
  • nucleotide
  • oncocytoma
  • renal cell carcinoma
  • renal oncocytoma

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