ArrayExpress Uploader03553endothelium cells from diffuse large B-cell lymphomaendothelium cells from diffuse large B-cell lymphomaendothelium cells from reactive lymph nodesendothelium cells from peripheral T cell lymphomaendothelium cells from reactive lymph nodesarrayexpress_sid4Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc....20176801E-GEOD-19882/profile/8773/arrayexpressuploader15b-cell lymphomacelldiffuse large b-cell lymphomaendotheliumlcmlymphlymph nodelymphomaperipheralDec.12, 2014Falseexpression-data-from-human-lymphoma-endothelium-anE-GEOD-19882_A-AFFY-44Expression data from human lymphoma endothelium and reactive lymph node-derived endotheliumSep.15, 2014Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc. Different gene expression profiles between lymphoma endothelium cells and reactive lymph node-derived endothelium cells may uncover these genes. And intensive mechanism researches on such key genes may explain the mechanisim of tumor-specific angiogenesis and help to explore effective treatment strategies to prevent/reverse tumor metastasis. We use microarrays to detail gene expression profiles of human lymphoma endothelium and reactive lymph node-derived endothelium. Lymph nodes were taken from surgery samples of cases pathologically diagnosed DLBCL (diffuse large B-cell lymphoma), PTL (peripheral T cell lymphoma) and reactive lymph nodes. The pure endothelium cells were isolated by LCM after immunohistochemical staining of CD34. We found Tim-3 was preferentially expressed on lymphoma-derived ECs via different expression profiles between lymphoma ECs and reactive lymph node-derived ECs. Intensive researches were carried out on Tim-3-expressing -ECs and we found that Tim-3 -expressing-Ecs may play important role on EC-mediated tumor evasion.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19882humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19882/samples/