{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3553, "factors": [{"GSM497078": {"CELL TYPE": "endothelium cells from diffuse large B-cell lymphoma"}}, {"GSM497078": {"CELL TYPE": "endothelium cells from diffuse large B-cell lymphoma"}}, {"GSM497080": {"CELL TYPE": "endothelium cells from reactive lymph nodes"}}, {"GSM49708": {"CELL TYPE": "endothelium cells from peripheral T cell lymphoma"}}, {"GSM497080": {"CELL TYPE": "endothelium cells from reactive lymph nodes"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc....", "pubmed_id": 20176801, "geo_gse_id": "E-GEOD-19882", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 5, "tags": ["b-cell lymphoma", "cell", "diffuse large b-cell lymphoma", "endothelium", "lcm", "lymph", "lymph node", "lymphoma", "peripheral"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-human-lymphoma-endothelium-an", "geo_id_plat": "E-GEOD-19882_A-AFFY-44", "name": "Expression data from human lymphoma endothelium and reactive lymph node-derived endothelium", "created": "Sep.15, 2014", "summary": "Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc. Different gene expression profiles between lymphoma endothelium cells and reactive lymph node-derived endothelium cells may uncover these genes. And intensive mechanism researches on such key genes may explain the mechanisim of tumor-specific angiogenesis and help to explore effective treatment strategies to prevent/reverse tumor metastasis. We use microarrays to detail gene expression profiles of human lymphoma endothelium and reactive lymph node-derived endothelium. Lymph nodes were taken from surgery samples of cases pathologically diagnosed DLBCL (diffuse large B-cell lymphoma), PTL (peripheral T cell lymphoma) and reactive lymph nodes. The pure endothelium cells were isolated by LCM after immunohistochemical staining of CD34. We found Tim-3 was preferentially expressed on lymphoma-derived ECs via different expression profiles between lymphoma ECs and reactive lymph node-derived ECs. Intensive researches were carried out on Tim-3-expressing -ECs and we found that Tim-3 -expressing-Ecs may play important role on EC-mediated tumor evasion.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19882", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19882/samples/"}