{"platform": 6, "owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM494396": {"GENOTYPE": "Wild type"}}, {"GSM494396": {"GENOTYPE": "Wild type"}}, {"GSM494398": {"GENOTYPE": "Ink4a/Arf-null"}}, {"GSM494398": {"GENOTYPE": "Ink4a/Arf-null"}}, {"GSM494400": {"GENOTYPE": "Bmi1-null"}}, {"GSM49440": {"GENOTYPE": "Bmi1/Ink4a/Arf-null"}}, {"GSM49440": {"GENOTYPE": "Bmi1/Ink4a/Arf-null"}}], "id": 5952, "pop_total": 0, "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19796", "summary_wrapped": "Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been...", "pubmed_id": 20207230, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 7, "tags": [], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-bmi1-null-c-kitsca-1lineage-m", "geo_id_plat": "E-GEOD-19796_A-AFFY-45", "name": "Expression data from Bmi1-null c-Kit+Sca-1+Lineage marker- (KSL) hematopoietic stem/progenitor cells", "created": "Nov.11, 2014", "summary": "Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized.  Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf 14.  Deletion of both Ink4a and Arf in Bmi1-deficient mice substantially restored the defective self-renewal capacity of HSCs and neural stem cells. Purified KSL cells from BM of wild-type, Bmi1-/-, Ink4a-/-Arf-/-, and  Bmi1-/- Ink4a-/-Arf-/- mice were subjected to RNA extraction and hybridization on Affymetrix microarrays.", "geo_gse_id": "E-GEOD-19796", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19796/samples/"}