ArrayExpress Uploader0humannormalnormalnormalnormalnormalnormalnormalintraductal papillary-mucinous adenoma (IPMA)intraductal papillary-mucinous adenoma (IPMA)intraductal papillary-mucinous adenoma (IPMA)intraductal papillary-mucinous adenoma (IPMA)intraductal papillary-mucinous adenoma (IPMA)intraductal papillary-mucinous adenoma (IPMA)intraductal papillary-mucinous carcinoma (IPMC)intraductal papillary-mucinous carcinoma (IPMC)intraductal papillary-mucinous carcinoma (IPMC)intraductal papillary-mucinous carcinoma (IPMC)intraductal papillary-mucinous carcinoma (IPMC)intraductal papillary-mucinous carcinoma (IPMC)intraductal papillary-mucinous neoplasm (IPMN)intraductal papillary-mucinous neoplasm (IPMN)intraductal papillary-mucinous neoplasm (IPMN)3534arrayexpress_sid4The host antitumor immunity changes drastically during carcinogenesis. Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is...E-GEOD-19650/profile/8773/arrayexpressuploader122adenomacancercarcinomaductinvasive carcinomamain pancreatic ductmucinous adenomamucinous neoplasmpancreaspancreatic cancerpancreatic ductDec.12, 2014FalseE-GEOD-19650_A-AFFY-44expression-data-from-epithelial-cells-during-the-pExpression data from epithelial cells during the process of multistep pancreatic carcinogenesisSep.15, 2014The host antitumor immunity changes drastically during carcinogenesis. Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a precursor lesion of pancreatic cancer and progresses according to adenoma-carcinoma sequence. We found that the host antitumor immune reaction changes from an immune response to immune tolerance between intraductal papillary-mucinous adenoma (IPMA) and intraductal papillary-mucinous carcinoma (IPMC). In order to determine molecules affecting intraepithelial DC infiltration in IPMNs during multistep carcinogenesis, we examined the gene-expression profiles of entire transcripts of neoplastic cells at different stages. We collected normal and neoplastic epithelial cells from frozen tissue sections (normal main pancreatic duct, IPMA, IPMC, and invasive carcinoma originating in IPMN) by laser microdissection, extracted total RNA from them, and analyzed their gene expression profiles using Affymetrix microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19650http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19650/samples/