Dataset: LNCaP cells in response to DHT stimulation and inhibition/knockdown of TOPO2B
Microarray experiments were carried out to ascertain whether TOP2β is required for DHT induced androgen receptor target gene expression....
Microarray experiments were carried out to ascertain whether TOP2β is required for DHT induced androgen receptor target gene expression. We investigated the effect of pharmacological inhibition or RNA interference-mediated depletion of TOP2β on gene expression in androgen-dependent LNCaP prostate cancer cells. Analysis of gene expression in LNCaP cells under various conditions including serum starvation, DHT treatment, and DHT treatment combined with TOPO2B pharmacological inhibitors (Merbarone and Etoposide) and TOPO2B-shRNA knockdown.
- Species:
- human
- Samples:
- 9
- Source:
- E-GEOD-19445
- PubMed:
- 20601956
- Updated:
- Dec.12, 2014
- Registered:
- Sep.15, 2014
Factors:
(via ArrayExpress)
| Sample | PROTOCOL |
|---|---|
| GSM484649 | steady state |
| GSM484650 | androgen deprivation |
| GSM484650 | androgen deprivation |
| GSM484652 | androgen deprivation + Etoposide |
| GSM484653 | androgen deprivation + Merbarone |
| GSM484654 | control transfection and androgen deprivation |
| GSM484654 | control transfection and androgen deprivation |
| GSM484656 | TOPO2B knockdown and androgen deprivation |
| GSM484656 | TOPO2B knockdown and androgen deprivation |