ArrayExpress Uploader09634SNC14.045femaleAFA406current smoker without cancerSNC2.032maleASI114current smoker without cancerSNC7.023maleAFA121current smoker without cancerNS0.028maleCAU90never smokerNS0.031maleCAU91never smokerNS0.028maleCAU95never smokerNS0.027femaleCAU97never smokerNS0.068maleCAU98never smokerNS0.025maleCAU116never smokerSNC3.048maleAFA77former smoker without cancerSNC122.571maleCAU26former smoker without cancerSNC0.527femaleAFA78former smoker without cancerNS0.068maleCAU98never smokerSNC25.039maleCAU102current smoker without cancerSNC4.030maleCAU103current smoker without cancerSNC0.527femaleAFA78former smoker without cancerSNC2.032maleASI114current smoker without cancerSNC2.032maleASI114current smoker without cancerSNC25.039maleCAU102current smoker without cancerSNC4.030maleCAU103current smoker without cancerSNC7.023maleASI187current smoker without cancerSC47.065femaleCAU216former smoker with cancerSC100.069femaleCAU238former smoker with cancerSC43.059maleCAU239current smoker with cancerSC76.059maleCAU263former smoker with cancerSC34.062maleCAU264former smoker with cancerSC120.062maleCAU266former smoker with cancerSC37.066maleCAU267current smoker with cancerSC37.066maleCAU267current smoker with cancerSC80.077femaleCAU268former smoker with cancerSNC70.071maleCAU269former smoker without cancerSC55.075maleCAU277current smoker with cancerSC38.054maleCAU285current smoker with cancerSNC22.058maleCAU313current smoker without cancerSNC114.069maleCAU312current smoker without cancerSNC232.071maleCAU317current smoker without cancerSNC80.071maleCAU318current smoker without cancerSNC25.069maleCAU319current smoker without cancerSNC64.079maleCAU323current smoker without cancerSC80.083maleCAU349former smoker with cancerSNC66.075maleCAU359former smoker without cancerSNC17.034maleAFA373current smoker without cancerSNC14.045femaleAFA406current smoker without cancerSNC84.063maleCAU430former smoker without cancerSC85.078maleCAU435former smoker with cancerSNC99.065maleCAU441former smoker without cancerSC9.070femaleCAU446former smoker with cancerSC57.083maleCAU450former smoker with cancerSC19.557maleAFA453current smoker with cancerSNC45.044maleAFA456current smoker without cancerSC23.075maleCAU457former smoker with cancerSNC27.540maleHIS459current smoker without cancerNS0.026femaleHIS460never smokerSNC57.050maleCAU462current smoker without cancerNS0.023femaleOTH464never smokerSC75.059maleCAU472current smoker with cancerSC75.067maleCAU478current smoker with cancerSC60.075maleCAU483former smoker with cancerSC51.257maleCAU485current smoker with cancerSNC63.065maleOTH508former smoker without cancerarrayexpress_sid3Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell...20689807E-GEOD-19027/profile/8773/arrayexpressuploader060cancercellcentralepithelial celllunglung cancerJan.17, 2015Falseantioxidant-response-gene-expression-in-the-bronchE-GEOD-19027_A-AFFY-33Antioxidant response gene expression in the bronchial airway epithelial cells of smokers at risk for lung cancerJan.17, 2015Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell gene expression response to smoking can serve as an early diagnostic biomarker for lung cancer. This study examines the relationship between gene expression variation and genetic variation in a central molecular pathway (NRF2-mediated antioxidant response) associated with smoking exposure and lung cancer. We assessed global gene expression in histologically normal airway epithelial cells obtained at bronchoscopy from smokers who developed lung cancer (SC, n=20), smokers without lung cancer (SNC, n=24), and never smokers (NS, n=8). Functional enrichment showed that the NRF2-mediated antioxidant response pathway differed significantly among these groups. Keywords: Global mRNA expression profiling 21 total arrays (20 unique patients) run on total RNA obtained from Bronchial Epithelium of Smokers with Lung Cancer 30 total arrays (24 unique patients) run on total RNA obtained from Bronchial Epithelium of Smokers without Lung Cancer 9 total arrays (8 unique patients) run on total RNA obtained from Bronchial Epithelium of Never Smokershttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19027humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-19027/samples/