ArrayExpress Uploaderarrayexpress_sidmousewild typewild typewild typewild typeHoxd4 transgenicHoxd4 transgenicHoxd4 transgenicHoxd4 transgenic589106Homeobox genes of the Hox class are required for proper patterning of skeletal elements and play a role in cartilage differentiation. In...E-GEOD-18991/profile/8773/arrayexpressuploader18classDec.12, 2014Falseoverexpression-of-hoxd4-transcription-factor-alterE-GEOD-18991_A-AFFY-45Overexpression of Hoxd4 transcription factor alters transcriptional profiles in mouse chondrocytes at E18.5Nov.11, 2014Homeobox genes of the Hox class are required for proper patterning of skeletal elements and play a role in cartilage differentiation. In transgenic mice with overexpression of Hoxd4 during cartilage development, we observed severe defects, namely physical instability of cartilage, accumulation of immature chondrocytes, and decreased maturation to hypertrophy. To define the molecular basis underlying these defects, we performed gene expression profiling using the Affymetrix microarray platform. Embryos were dissected from four different mouse litters at E18.5. Embryos from each litter were grouped according their genotype: TA=control; TR=transgenic.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18991http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18991/samples/