{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM468776": {"GENOTYPE": "Wild-type"}}, {"GSM468776": {"GENOTYPE": "Wild-type"}}, {"GSM468778": {"GENOTYPE": "Cnot3 heterozygotes"}}, {"GSM468778": {"GENOTYPE": "Cnot3 heterozygotes"}}], "id": 5887, "pop_total": 0, "platform": 6, "summary_wrapped": "Decay of mRNAs initiates with shortening of the poly(A) tail. Although the CCR4-NOT complex participates in deadenylation, how it becomes...", "geo_gse_id": "E-GEOD-18924", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 4, "tags": ["glucose", "lipid", "liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-18924_A-AFFY-45", "slug": "expression-data-from-the-liver-of-wild-type-and-cn", "geo_gds_id": "", "name": "Expression data from the liver of wild-type and Cnot3+/- mice: Fasted", "created": "Nov.11, 2014", "summary": "Decay of mRNAs initiates with shortening of the poly(A) tail. Although the CCR4-NOT complex participates in deadenylation, how it becomes activates remain obscure. We show that complete deficiency in CNOT3, subunit 3 of this complex, is lethal in mice, but that heterozygotes survive as lean mice with hepatic and adipose tissues containing reduced lipid levels. Cnot3+/- mice have enhanced metabolic rates and remain lean on high-fat diets. To examine the underlying mechanisms by which CNOT3 is involved in the control of metabolic balance, we compared the gene expression profiles of wild-type and Cnot3+/- mice using Affymetrix microarray technology. We chose to analyze the liver because the CNOT3 level in the liver was affected by the feeding condition and because the liver plays a major role in glucose and lipid metabolism. The livers were isolated from 12-week-old wild-type and Cnot3+/- mice (n = 2 for each genotype).", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18924", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18924/samples/"}