ArrayExpress Uploaderarrayexpress_sid3483MCF-7MCF-7MCF-7MCF-7MCF-7MCF-7R4MCF-7R4MCF-7R4MCF-7R4MCF-7R404Human breast cancer cell line MCF-7 is usually sensitive to chemotherapy drug BMS-554417, an insulin receptor (IR) and insulin-like...21220496E-GEOD-18912/profile/8773/arrayexpressuploader110breastbreast cancercancercellinsulinlineDec.12, 2014FalseE-GEOD-18912_A-AFFY-44expression-profiling-of-breast-cancer-cell-lines-mExpression profiling of breast cancer cell lines MCF-7 and MCF-7R4Sep.15, 2014Human breast cancer cell line MCF-7 is usually sensitive to chemotherapy drug BMS-554417, an insulin receptor (IR) and insulin-like growth factor receptor (IGFR) inhibitor. However, through step-wise increase in BMS-554417 doses in culture media, we were able able to screen and select a single MCF-7 clone that is BMS-554417 resistant. It is cross resistant to BMS-536924. This new line of MCF-7 cells was named as MCF-7R4. The transcriptome profiling of both MCF-7 and MCF-7R4 was performed using Affymetrix HG-U133 plus2.0 GeneChip arrays. Five replicates of MCF-7 and five replicates of MCF-7R4 were profiled.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18912humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18912/samples/