{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 3483, "factors": [{"GSM468593": {"CELL LINE": "MCF-7"}}, {"GSM468593": {"CELL LINE": "MCF-7"}}, {"GSM468593": {"CELL LINE": "MCF-7"}}, {"GSM468593": {"CELL LINE": "MCF-7"}}, {"GSM468593": {"CELL LINE": "MCF-7"}}, {"GSM468598": {"CELL LINE": "MCF-7R4"}}, {"GSM468598": {"CELL LINE": "MCF-7R4"}}, {"GSM468598": {"CELL LINE": "MCF-7R4"}}, {"GSM468598": {"CELL LINE": "MCF-7R4"}}, {"GSM468598": {"CELL LINE": "MCF-7R4"}}], "pop_total": 0, "platform": 4, "summary_wrapped": "Human breast cancer cell line MCF-7 is usually sensitive to chemotherapy drug BMS-554417, an insulin receptor (IR) and insulin-like...", "pubmed_id": 21220496, "geo_gse_id": "E-GEOD-18912", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 10, "tags": ["breast", "breast cancer", "cancer", "cell", "insulin", "line"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-18912_A-AFFY-44", "slug": "expression-profiling-of-breast-cancer-cell-lines-m", "geo_gds_id": "", "name": "Expression profiling of breast cancer cell lines MCF-7 and MCF-7R4", "created": "Sep.15, 2014", "summary": "Human breast cancer cell line MCF-7 is usually sensitive to chemotherapy drug BMS-554417, an insulin receptor (IR) and insulin-like growth factor receptor (IGFR) inhibitor. However, through step-wise increase in BMS-554417 doses in culture media, we were able able to screen and select a single MCF-7 clone that is BMS-554417 resistant.  It is cross resistant to BMS-536924. This new line of MCF-7 cells was named as MCF-7R4. The transcriptome profiling of both MCF-7 and MCF-7R4 was performed using Affymetrix HG-U133 plus2.0 GeneChip arrays. Five replicates of MCF-7 and five replicates of MCF-7R4 were profiled.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18912", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18912/samples/"}