{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM586978": {"CELL LINE": "NMC cell line TC-797", "AGENT": "ethanol vehicle control"}}, {"GSM586978": {"CELL LINE": "NMC cell line TC-797", "AGENT": "ethanol vehicle control"}}, {"GSM586978": {"CELL LINE": "NMC cell line TC-797", "AGENT": "ethanol vehicle control"}}, {"GSM58698": {"CELL LINE": "NMC cell line TC-797", "AGENT": "trichostatin (TSA)"}}, {"GSM58698": {"CELL LINE": "NMC cell line TC-797", "AGENT": "trichostatin (TSA)"}}, {"GSM58698": {"CELL LINE": "NMC cell line TC-797", "AGENT": "trichostatin (TSA)"}}, {"GSM586984": {"CELL LINE": "NMC cell line TC-797", "AGENT": "scrambled control siRNA"}}, {"GSM586984": {"CELL LINE": "NMC cell line TC-797", "AGENT": "scrambled control siRNA"}}, {"GSM586986": {"CELL LINE": "NMC cell line TC-797", "AGENT": "NUT siRNA"}}, {"GSM586986": {"CELL LINE": "NMC cell line TC-797", "AGENT": "NUT siRNA"}}, {"GSM586988": {"CELL LINE": "NMC cell line PER-403", "AGENT": "ethanol vehicle control"}}, {"GSM586988": {"CELL LINE": "NMC cell line PER-403", "AGENT": "ethanol vehicle control"}}, {"GSM586988": {"CELL LINE": "NMC cell line PER-403", "AGENT": "ethanol vehicle control"}}, {"GSM58699": {"CELL LINE": "NMC cell line PER-403", "AGENT": "trichostatin (TSA)"}}, {"GSM58699": {"CELL LINE": "NMC cell line PER-403", "AGENT": "trichostatin (TSA)"}}, {"GSM58699": {"CELL LINE": "NMC cell line PER-403", "AGENT": "trichostatin (TSA)"}}, {"GSM586994": {"CELL LINE": "NMC cell line PER-403", "AGENT": "scrambled control siRNA"}}, {"GSM586994": {"CELL LINE": "NMC cell line PER-403", "AGENT": "scrambled control siRNA"}}, {"GSM586996": {"CELL LINE": "NMC cell line PER-403", "AGENT": "NUT siRNA"}}, {"GSM586996": {"CELL LINE": "NMC cell line PER-403", "AGENT": "NUT siRNA"}}], "id": 3460, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Knockdown of the oncogene, BRD4-NUT, in a rare cancer, termed NUTmidline carcinoma (NMC), results in morphologic features consistent with...", "geo_gse_id": "E-GEOD-18668", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 20, "tags": ["cancer", "carcinoma", "cell", "squamous"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "differentiation-of-nut-midline-carcinoma-by-epigen", "geo_id_plat": "E-GEOD-18668_A-AFFY-44", "name": "Differentiation of NUT midline carcinoma by epigenomic reprogramming", "created": "Sep.15, 2014", "summary": "Knockdown of the oncogene, BRD4-NUT, in a rare cancer, termed NUTmidline carcinoma (NMC), results in morphologic features consistent with squamous differentiation.  Treatment with the HDAC-inhibitor, TSA, appears to cause the same phenotype.  Here, we use gene expression profiling to compare the changes in gene expression following BRD4-NUT knockdown and TSA treatment. RNA was extracted from two BRD4-NUT-expressing NMC cell lines, PER-403 and TC-797, 24h following siRNA knockdown versus control in duplicate. RNA was extracted from two BRD4-NUT-expressing NMC cell lines, PER-403 and TC-797,  24h following treatment with TSA versus etoh control in triplicate", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18668", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18668/samples/"}