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Home › Dataset Library › Transcriptional Profiling of CD133+ Cells in Coronary Artery Disease and Effects of Exercise on Gene Expression

Dataset: Transcriptional Profiling of CD133+ Cells in Coronary Artery Disease and Effects of Exercise on Gene Expression

Bone marrow-derived progenitor cells are under investigation for cardiovascular repair, but may be altered by disease. We identified 82...

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Bone marrow-derived progenitor cells are under investigation for cardiovascular repair, but may be altered by disease. We identified 82 differentially expressed genes in CD133+ cells from patients with coronary artery disease (CAD) versus controls, of which 59 were found to be up-regulated and 23 down-regulated. These genes were found to be involved in carbohydrate metabolism, cellular development and signaling, molecular transport and cell differentiation. Following completion of an exercise program, gene expression patterns resembled those of controls in 7 of 10 patients. Blood sampled from 4 healthy subjects (H), and from 10 patients with coronary artery disease at baseline (A) and after 3 months (B) of exercise.

Species:
human

Samples:
24

Source:
E-GEOD-18608

Updated:
Dec.12, 2014

Registered:
Sep.15, 2014


Factors: (via ArrayExpress)
Sample DISEASE TREATMENT
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462608 coronary artery disease baseline
GSM462609 coronary artery disease 3 months of exercise
GSM462628 healthy not specified
GSM462628 healthy not specified
GSM462628 healthy not specified
GSM462628 healthy not specified

Tags

  • artery
  • artery disease
  • bone
  • bone marrow
  • carbohydrate
  • cell
  • coronary artery
  • coronary artery disease
  • disease

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