{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM462596 1": {}}, {"GSM462597 1": {}}, {"GSM462598 1": {}}, {"GSM462599 1": {}}, {"GSM462600 1": {}}, {"GSM462601 1": {}}, {"GSM462602 1": {}}, {"GSM462603 1": {}}, {"GSM462604 1": {}}, {"GSM462605 1": {}}, {"GSM462606 1": {}}, {"GSM462607 1": {}}], "id": 5865, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Type I IFN-signaling suppresses an excessive IFN-{gamma} response and prevents lung damage and chronic inflammation following...", "pubmed_id": 20395428, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 12, "tags": ["cell", "collagen", "lung"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-18607_A-AFFY-45", "slug": "type-i-ifn-signaling-following-pneumocystis-pc-inf", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18607", "geo_gds_id": "", "name": "Type I IFN-signaling following Pneumocystis (PC)-infection and clearance in CD4 T cell-competent mice", "created": "Nov.11, 2014", "summary": "Type I IFN-signaling suppresses an excessive IFN-{gamma} response and prevents lung damage and chronic inflammation following Pneumocystis (PC)-infection and clearance in CD4 T cell-competent mice. Type I IFN -signaling in pulmonary CD11c+ DCs and alveolar macrophages may prevent chronic inflammation following PC lung infection and clearance by suppressing an excessive IFN-g-response via the induction of SOCS1. IFNAR-/- and wildtype mice were both Pneumocystis infected via itratracheal instillation. Pulmonary CD11c+ cells were isolated from collagen digested lungs at day 7 and day 14 post infection from both wildtype and IFNAR-/- mice using a magnetic cell sorting technique from Miltenyi with CD11c microbeads. Cells from three individual animals per group were isolated and assessed. Comparison of 2 treatment types at 2 timepoints to determine whether type I IFN signaling is initiated in resident and early recruited pulmonary CD11c+ cells following Pneumocystis lung infection and whether this is relevant to the outcome of the inflammatory response during the initiation of clearance.", "geo_gse_id": "E-GEOD-18607", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18607/samples/"}