ArrayExpress Uploader0human3442arrayexpress_sid4The PLZF-RARa fusion oncoprotein is overexpressed in the t(11;17) subtype of acute promyelocytic leukemia. Gene expression microarrays...E-GEOD-18476/profile/8773/arrayexpressuploader06cellleukemialineDec.12, 2014Falsetranscription-profiling-of-human-u937tplzf-rara-inE-GEOD-18476_A-AFFY-44Transcription profiling of human U937T:PLZF-RARa Inducible CellsSep.15, 2014The PLZF-RARa fusion oncoprotein is overexpressed in the t(11;17) subtype of acute promyelocytic leukemia. Gene expression microarrays were used to identify genes involved in leukemic transformation. We used microarray to detect gene expression changes induced by the PLZF-RARa fusion oncoprotein in the U937 cell line Experiment Overall Design: The U937T:PLZF-RARa cell line was engineered to express PLZF-RARa upon tetracycline removal. PLZF-RARa was induced for 48hr and RNA was extracted and hybridized to Affymetrix HGU133Plus2.0 Chipshttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18476http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18476/samples/