{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM455430": {"GENDER": "female", "GENOTYPE": "Gnmt knockout"}}, {"GSM45543": {"GENDER": "female", "GENOTYPE": "wild-type"}}, {"GSM455432": {"GENDER": "male", "GENOTYPE": "Gnmt knockout"}}, {"GSM455433": {"GENDER": "male", "GENOTYPE": "wild-type"}}], "id": 5834, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "We report that liver nodules from 5/8 (62.5%) male and 4/5 (80%) female Gnmt-/- mice were diagnosed as having HCC. Microarray analysis...", "geo_gse_id": "E-GEOD-18218", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 4, "tags": ["cancer", "cell", "hcc", "liver", "liver cancer", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-afb1-treated-gnmt-knockout-mi", "geo_id_plat": "E-GEOD-18218_A-AFFY-45", "name": "Expression data from AFB1-treated GNMT knockout mice", "created": "Nov.11, 2014", "summary": "We report that liver nodules from 5/8 (62.5%) male and 4/5 (80%) female Gnmt-/- mice were diagnosed as having HCC. Microarray analysis showed that genes involved in the following pathways were deregulated in different stages of tumorigenesis: Methylation, metabolism, signal transduction, cell proliferation, and cell adhesion. This study reveals that GNMT plays an important role in the prevention of hepatotumorigenesis through regulating detoxification pathways. We postulate that GNMT is a stress-responsive protein and its expression may account for the gender difference of the susceptibility to liver cancer. Liver tissues from aflatoxin B1 (AFB1)-treated wild-type or Gnmt knockout mice at 11weeks old were used for RNA extraction and hybridization on Affymetrix microarrays. Total RNA were mixed in equal proportion from 3 mice.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18218", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18218/samples/"}