{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSE18000GSM450427": {}}, {"GSE18000GSM450428": {}}], "id": 3408, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "We recently identified the nonreceptor tyrosine kinase syk as a tumor suppressor in pancreatic ductal adenocarcinoma cells....", "geo_gse_id": "E-GEOD-18000", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 2, "tags": ["adenocarcinoma", "axis", "ductal adenocarcinoma", "pancreatic ductal adenocarcinoma", "tyrosine"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-human-drug-resistant-pa", "geo_id_plat": "E-GEOD-18000_A-AFFY-44", "name": "Transcription profiling of human drug-resistant Panc1/mock cells and Panc1 cells expressing wildtype syk", "created": "Sep.15, 2014", "summary": "We recently identified the nonreceptor tyrosine kinase syk as a tumor suppressor in pancreatic ductal adenocarcinoma cells.  Reintroduction of syk into Panc1 cells promoted a more differentiated phenotype and retarded invasion and tumorigenic growth. Gene array analysis identified over 2,000 transcripts differentially expressed at FDR<0.01.  Among these were members of the MMP2 axis, which were subsequently shown to regulate Panc1 invasion. Experiment Overall Design: Affymetrix global gene arrays were used to analyse differences in gene expression patterns in Panc1 cells stably reexpressing syk, or vector-only mock controls.  RNA was harvested from cells grown under identical conditions in standard culture.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18000", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18000/samples/"}