ArrayExpress Uploader0human3408arrayexpress_sid4We recently identified the nonreceptor tyrosine kinase syk as a tumor suppressor in pancreatic ductal adenocarcinoma cells....E-GEOD-18000/profile/8773/arrayexpressuploader02adenocarcinomaaxisductal adenocarcinomapancreatic ductal adenocarcinomatyrosineDec.12, 2014Falsetranscription-profiling-of-human-drug-resistant-paE-GEOD-18000_A-AFFY-44Transcription profiling of human drug-resistant Panc1/mock cells and Panc1 cells expressing wildtype sykSep.15, 2014We recently identified the nonreceptor tyrosine kinase syk as a tumor suppressor in pancreatic ductal adenocarcinoma cells. Reintroduction of syk into Panc1 cells promoted a more differentiated phenotype and retarded invasion and tumorigenic growth. Gene array analysis identified over 2,000 transcripts differentially expressed at FDR<0.01. Among these were members of the MMP2 axis, which were subsequently shown to regulate Panc1 invasion. Experiment Overall Design: Affymetrix global gene arrays were used to analyse differences in gene expression patterns in Panc1 cells stably reexpressing syk, or vector-only mock controls. RNA was harvested from cells grown under identical conditions in standard culture.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18000http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-18000/samples/