4ArrayExpress Uploaderarrayexpress_sidhumankit expression: highKIT mutation; PDGFRA wild typekit expression: highKIT mutation; PDGFRA wild typekit expression: highKIT mutation; PDGFRA wild typekit expression: lowKIT wild type; PDGFRA mutationkit expression: highKIT mutation; PDGFRA wild typekit expression: highKIT mutation; PDGFRA wild typekit expression: highKIT mutation; PDGFRA wild typekit expression: lowKIT wild type; PDGFRA wild typekit expression: highKIT wild type; PDGFRA wild typekit expression: highKIT mutation; PDGFRA wild typekit expression: highKIT mutation; PDGFRA wild typekit expression: lowKIT wild type; PDGFRA mutationkit expression: lowKIT wild type; PDGFRA mutationkit expression: lowKIT wild type; PDGFRA mutationkit expression: lowKIT wild type; PDGFRA mutationkit expression: lowKIT wild type; PDGFRA wild typekit expression: highKIT wild type; PDGFRA mutationkit expression: lowKIT wild type; PDGFRA mutationkit expression: highKIT mutation; PDGFRA wild typekit expression: lowKIT wild type; PDGFRA mutationkit expression: lowKIT wild type; PDGFRA mutationkit expression: lowKIT mutation; PDGFRA wild typekit expression: lowKIT mutation; PDGFRA wild typekit expression: highKIT mutation; PDGFRA wild typekit expression: highKIT mutation; PDGFRA wild typekit expression: lowKIT wild type; PDGFRA mutationkit expression: highKIT mutation; PDGFRA wild typekit expression: MEDIUMKIT wild type; PDGFRA mutationkit expression: highKIT mutation; PDGFRA wild type33940http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17743Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-...19943934/profile/8773/arrayexpressuploader229gisttyrosineDec.12, 2014Falsetranscription-profiling-by-array-of-human-gastroinE-GEOD-17743_A-AFFY-44Transcription profiling by array of human gastrointestinal stromal tumours mutant for KIT and/or PDGFRASep.15, 2014Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-function mutations in KIT or PDGFRA of the type III receptor tyrosine kinase family. Although mutations in either receptor are thought to drive an early oncogenic event through similar pathways, two previous studies reported the mutation-specific gene expression profiles. However, their further conclusions were rather discordant. To clarify the molecular characteristics of differentially expressed genes according to GIST receptor mutations, we combined microarray-based analysis with detailed functional annotations. Experiment Overall Design: 29 samples: 15 with KIT mutation detected, 11 with PDGFRA mutation detected, 3 with no mutation detectedE-GEOD-17743http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17743/samples/