{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 5791, "factors": [{"GSM442563": {"GENOTYPE": "STAT5 WT"}}, {"GSM442564": {"GENOTYPE": "STAT5 KO"}}, {"GSM442563": {"GENOTYPE": "STAT5 WT"}}, {"GSM442564": {"GENOTYPE": "STAT5 KO"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B that mediate cytokine signaling.  To reveal the...", "pubmed_id": 19833766, "geo_gse_id": "E-GEOD-17723", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 4, "tags": ["cell", "cytokine", "luminal", "stem cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "development-of-mammary-luminal-progenitor-cells-is", "geo_id_plat": "E-GEOD-17723_A-AFFY-45", "name": "Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A", "created": "Nov.11, 2014", "summary": "Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B that mediate cytokine signaling.  To reveal the underlying causes for this developmental block we studied mammary stem and progenitor cells.  While loss of STAT5A/5B did not affect the stem cell population and their ability to form mammary ducts, luminal progenitors were greatly reduced and unable to form alveoli during pregnancy.  Temporally-controlled expression of transgenic STAT5A in mammary epithelium lacking STAT5A/5B restored the luminal progenitor population and rescued alveologenesis in a reversible fashion in vivo.  Taken together, STAT5A is necessary and sufficient for the establishment of luminal progenitor cells. The mammary tissues from two mice of each genotype were collected 6 days (sample 9 and 11 were WT)", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17723", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17723/samples/"}