{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM442052": {"GENOME/VARIATION": "wild type, PTIP+", "DEVELOPMENTAL STAGE": "1 month old"}}, {"GSM442053": {"GENOME/VARIATION": "wild type, PTIP+", "DEVELOPMENTAL STAGE": "2 month old"}}, {"GSM442054": {"GENOME/VARIATION": "wild type, PTIP+", "DEVELOPMENTAL STAGE": "3 month old"}}, {"GSM442055": {"GENOME/VARIATION": "wild type, PTIP+", "DEVELOPMENTAL STAGE": "4 month old"}}, {"GSM442056": {"GENOME/VARIATION": "wild type, PTIP+", "DEVELOPMENTAL STAGE": "5 month old"}}, {"GSM442057": {"GENOME/VARIATION": "wild type, PTIP+", "DEVELOPMENTAL STAGE": "6 month old"}}, {"GSM442058": {"GENOME/VARIATION": "wild type, PTIP+", "DEVELOPMENTAL STAGE": "7 month old"}}, {"GSM442059": {"GENOME/VARIATION": "wild type, PTIP+", "DEVELOPMENTAL STAGE": "8 month old"}}, {"GSM442060": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "9 month old"}}, {"GSM44206": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "10 month old"}}, {"GSM442062": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "11 month old"}}, {"GSM442063": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "12 month old"}}, {"GSM442064": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "13 month old"}}, {"GSM442065": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "14 month old"}}, {"GSM442066": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "15 month old"}}, {"GSM442067": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "16 month old"}}, {"GSM442068": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "17 month old"}}, {"GSM442069": {"GENOME/VARIATION": "Pod-Cre, PTIP-", "DEVELOPMENTAL STAGE": "18 month old"}}], "id": 5790, "pop_total": 0, "platform": 6, "summary_wrapped": "Glomerular RNA comparison between wild-type and podocyte specific deletion of the PTIP gene in 1 month old kidneys. The PTIP gene was...", "geo_gse_id": "E-GEOD-17709", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 18, "tags": ["protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-analysis-of-a-podocyte-specific-pt", "geo_id_plat": "E-GEOD-17709_A-AFFY-45", "name": "Gene expression analysis of a podocyte specific PTIP deletion in mouse glomerular preparations at 1 month of age", "created": "Nov.11, 2014", "summary": "Glomerular RNA comparison between wild-type and podocyte specific deletion of the PTIP gene in 1 month old kidneys. The PTIP gene was deleted using a floxed allele and a Podocin-Cre driver strain.  These mice develop protein urea by 3 months of age. This study was designed to find gene expression differences prior to the onset of the phenotype. A ptip floxed allele was crossed into the Podocin-Cre expressing strain to generate ptip fl/fl homozygous mice or ptip fl/- transheterozygous mice with or without the Cre expressing transgene. Animals were genotyped and assigend into two groups: Mutants with PTIP deletion (PTIP-) with the genotype ptip fl/fl:Pod-Cre or ptip fl/-:Pod-Cre or control mice (PTIP+) with either ptip fl/fl or ptip fl/-. Note that the floxed allele produced normal levels of wild-type PTIP protein.  Kidneys were excised at 1 month of age. Glomeruli enriched fractions were generated by sieving of the tissue homogenates. RNA was prepared from glomerular enriched fractions.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17709", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17709/samples/"}