ArrayExpress Uploader05761Wild-typenoneWild-typenoneWild-typenoneWild-typenoneWild-typenoneWild-typeTNFa-treatedWild-typeTNFa-treatedWild-typeLPS-treatedWild-typeLPS-treatedWild-typeTSG6-treatedWild-typeTSG6-treatedWild-typeHA-treatedWild-typeHA-treatedWild-typeTSG6+HA-treatedWild-typeTSG6+HA-treatedTSG-6 knockoutnoneTSG-6 knockoutnoneTSG-6 knockoutnoneTSG-6 knockoutnoneTSG-6 knockoutnoneTSG-6 knockoutnoneTSG-6 knockoutnoneTSG-6 knockoutnoneTSG-6 knockoutTNFa-treatedTSG-6 knockoutTNFa-treatedTSG-6 knockoutTNFa-treatedTSG-6 knockoutTNFa-treatedTSG-6 knockoutLPS-treatedTSG-6 knockoutLPS-treatedTSG-6 knockoutLPS-treatedTSG-6 knockoutLPS-treatedTSG-6 knockoutTSG6-treatedTSG-6 knockoutTSG6-treatedTSG-6 knockoutTSG6-treatedTSG-6 knockoutHA-treatedTSG-6 knockoutHA-treatedTSG-6 knockoutHA-treatedTSG-6 knockoutHA-treatedTSG-6 knockoutTSG6+HA-treatedTSG-6 knockoutTSG6+HA-treatedTSG-6 knockoutTSG6+HA-treatedTSG-6 knockoutTSG6+HA-treatedarrayexpress_sid6BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), and the absence of TSG-6 further increases...21566135E-GEOD-17160/profile/8773/arrayexpressuploader242aggrecanarthritisfibroblastneutrophilproteoglycanDec.12, 2014FalseE-GEOD-17160_A-AFFY-45regulatory-mechanisms-of-tsg-6-tnf-alfa-induced-prRegulatory mechanisms of TSG-6 (TNF-alfa-induced protein-6: Tnfip6)-deficient and wild-type synovial fibroblastsNov.11, 2014BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), and the absence of TSG-6 further increases susceptibility and local inflammatory reactions, including neutrophil invasion into the joints. To gain insight into the mechanisms of TSG-6 action, synovial fibroblasts were isolated from wild-type and TSG-6-KO mice, cultured and exposed to various agents affecting either the TSG-6 expression and/or modify the intracellular function of TSG-6. In the present microarray studies, we have identified differences in gene expression by fibroblasts isolated from wild-type or TSG-6-KO mice Keywords: Genetic modification In this study we compared the gene expression profile of 42 fibroblast cultures from mouse synovial samples. Fifteen samples were wild-type and 27 samples were TSG-6 knockout. In these two genotype groups fibroblasts were treated with TNFa, LPS, TSG-6, HA, or HA+TSG-6, and were compared to untreated samples in the same genotype group. We also compared the same treatments between KO and WT.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17160mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17160/samples/