{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 5761, "factors": [{"GSM429336": {"TYPE": "Wild-type", "TREATMENT": "none"}}, {"GSM429336": {"TYPE": "Wild-type", "TREATMENT": "none"}}, {"GSM429336": {"TYPE": "Wild-type", "TREATMENT": "none"}}, {"GSM429336": {"TYPE": "Wild-type", "TREATMENT": "none"}}, {"GSM429336": {"TYPE": "Wild-type", "TREATMENT": "none"}}, {"GSM42934": {"TYPE": "Wild-type", "TREATMENT": "TNFa-treated"}}, {"GSM42934": {"TYPE": "Wild-type", "TREATMENT": "TNFa-treated"}}, {"GSM429343": {"TYPE": "Wild-type", "TREATMENT": "LPS-treated"}}, {"GSM429343": {"TYPE": "Wild-type", "TREATMENT": "LPS-treated"}}, {"GSM429345": {"TYPE": "Wild-type", "TREATMENT": "TSG6-treated"}}, {"GSM429345": {"TYPE": "Wild-type", "TREATMENT": "TSG6-treated"}}, {"GSM429347": {"TYPE": "Wild-type", "TREATMENT": "HA-treated"}}, {"GSM429347": {"TYPE": "Wild-type", "TREATMENT": "HA-treated"}}, {"GSM429349": {"TYPE": "Wild-type", "TREATMENT": "TSG6+HA-treated"}}, {"GSM429349": {"TYPE": "Wild-type", "TREATMENT": "TSG6+HA-treated"}}, {"GSM42935": {"TYPE": "TSG-6 knockout", "TREATMENT": "none"}}, {"GSM42935": {"TYPE": "TSG-6 knockout", "TREATMENT": "none"}}, {"GSM42935": {"TYPE": "TSG-6 knockout", "TREATMENT": "none"}}, {"GSM42935": {"TYPE": "TSG-6 knockout", "TREATMENT": "none"}}, {"GSM42935": {"TYPE": "TSG-6 knockout", "TREATMENT": "none"}}, {"GSM42935": {"TYPE": "TSG-6 knockout", "TREATMENT": "none"}}, {"GSM42935": {"TYPE": "TSG-6 knockout", "TREATMENT": "none"}}, {"GSM42935": {"TYPE": "TSG-6 knockout", "TREATMENT": "none"}}, {"GSM429359": {"TYPE": "TSG-6 knockout", "TREATMENT": "TNFa-treated"}}, {"GSM429359": {"TYPE": "TSG-6 knockout", "TREATMENT": "TNFa-treated"}}, {"GSM429359": {"TYPE": "TSG-6 knockout", "TREATMENT": "TNFa-treated"}}, {"GSM429359": {"TYPE": "TSG-6 knockout", "TREATMENT": "TNFa-treated"}}, {"GSM429363": {"TYPE": "TSG-6 knockout", "TREATMENT": "LPS-treated"}}, {"GSM429363": {"TYPE": "TSG-6 knockout", "TREATMENT": "LPS-treated"}}, {"GSM429363": {"TYPE": "TSG-6 knockout", "TREATMENT": "LPS-treated"}}, {"GSM429363": {"TYPE": "TSG-6 knockout", "TREATMENT": "LPS-treated"}}, {"GSM429367": {"TYPE": "TSG-6 knockout", "TREATMENT": "TSG6-treated"}}, {"GSM429367": {"TYPE": "TSG-6 knockout", "TREATMENT": "TSG6-treated"}}, {"GSM429367": {"TYPE": "TSG-6 knockout", "TREATMENT": "TSG6-treated"}}, {"GSM429370": {"TYPE": "TSG-6 knockout", "TREATMENT": "HA-treated"}}, {"GSM429370": {"TYPE": "TSG-6 knockout", "TREATMENT": "HA-treated"}}, {"GSM429370": {"TYPE": "TSG-6 knockout", "TREATMENT": "HA-treated"}}, {"GSM429370": {"TYPE": "TSG-6 knockout", "TREATMENT": "HA-treated"}}, {"GSM429374": {"TYPE": "TSG-6 knockout", "TREATMENT": "TSG6+HA-treated"}}, {"GSM429374": {"TYPE": "TSG-6 knockout", "TREATMENT": "TSG6+HA-treated"}}, {"GSM429374": {"TYPE": "TSG-6 knockout", "TREATMENT": "TSG6+HA-treated"}}, {"GSM429374": {"TYPE": "TSG-6 knockout", "TREATMENT": "TSG6+HA-treated"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), and the absence of TSG-6 further increases...", "pubmed_id": 21566135, "geo_gse_id": "E-GEOD-17160", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 42, "tags": ["aggrecan", "arthritis", "fibroblast", "neutrophil", "proteoglycan"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-17160_A-AFFY-45", "slug": "regulatory-mechanisms-of-tsg-6-tnf-alfa-induced-pr", "geo_gds_id": "", "name": "Regulatory mechanisms of TSG-6 (TNF-alfa-induced protein-6: Tnfip6)-deficient and wild-type synovial fibroblasts", "created": "Nov.11, 2014", "summary": "BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), and the absence of TSG-6 further increases susceptibility and local inflammatory reactions, including neutrophil invasion into the joints. To gain insight into the mechanisms of TSG-6 action, synovial fibroblasts were isolated from wild-type and TSG-6-KO mice, cultured and exposed to various agents affecting either the TSG-6 expression and/or modify the intracellular function of TSG-6. In the present microarray studies, we have identified differences in gene expression by fibroblasts isolated from wild-type or TSG-6-KO mice  Keywords: Genetic modification In this study we compared the gene expression profile of 42 fibroblast cultures from mouse synovial samples. Fifteen samples were wild-type and 27 samples were TSG-6 knockout. In these two genotype groups fibroblasts were treated with TNFa, LPS, TSG-6, HA, or HA+TSG-6, and were compared to untreated samples in the same genotype group. We also compared the same treatments between KO and WT.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17160", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-17160/samples/"}