ArrayExpress Uploaderarrayexpress_sidhuman3 years1104, control, skin fibroblasts5 years2433, control, skin fibroblasts8 years5042, control, skin fibroblasts7 years5290, control, skin fibroblasts3 years5850, control, skin fibroblasts4 years6089, control, skin fibroblasts5 years8495, control, skin fibroblasts5 years9118, control, skin fibroblasts3 years9837, control, skin fibroblasts8 years4319, WBS, skin fibroblasts7 years10358, WBS, skin fibroblasts3 years10590, WBS, skin fibroblasts3 yearsD890, WBS, skin fibroblasts4 yearsF055, WBS, skin fibroblasts4 yearsF223, WBS, skin fibroblasts3 yearsF348, WBS, skin fibroblasts7 yearsH652, WBS, skin fibroblasts332704Williams-Beuren Syndrome (WBS) is a neurodevelopmental disorder caused by aa 1.5 Mb microdeletion on human chromosome 7. Although the...21304579E-GEOD-16715/profile/8773/arrayexpressuploader217cellchromosomediseasefibroblastserumskinsyndromewilliams-beuren syndromeDec.12, 2014FalseE-GEOD-16715_A-AFFY-44expression-profiling-in-williams-beuren-syndrome-pExpression profiling in Williams-Beuren Syndrome patient fibroblast cell linesSep.12, 2014Williams-Beuren Syndrome (WBS) is a neurodevelopmental disorder caused by aa 1.5 Mb microdeletion on human chromosome 7. Although the molecular cause of the disorder is well-established, little is known about the global impact of the deletion on gene expression. Here we profiled the transcriptomes of fibroblast cell lines from 8 young girls with WBS, and 9 sex- and age-matched control individuals Keywords: disease state analysis, gene expression profiling Skin fibroblast of 8 WBS and 9 control individuals were obtained from the cell culture collections of the “Centre de Biotechnologie Cellulaire, Hospices Civils de Lyon, Hôpital Debrousse”, Lyon, France. Appropriate informed consent was obtained for each sample by the physicians in charge. Human skin fibroblasts were grown in HAM F-10, supplemented with 10% fetal bovine serum and 1% antibiotics (Invitrogen). Total RNA was prepared using TriZOL Reagent (Invitrogen) and RNeasy Mini Columns (Qiagen) according to the manufacturers’ instructions.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16715http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16715/samples/