{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM406482": {"TREATMENT": "Air"}}, {"GSM406482": {"TREATMENT": "Air"}}, {"GSM406482": {"TREATMENT": "Air"}}, {"GSM406482": {"TREATMENT": "Air"}}, {"GSM406482": {"TREATMENT": "Air"}}, {"GSM406487": {"TREATMENT": "Carbon Monoxide Gas (250 ppm)"}}, {"GSM406487": {"TREATMENT": "Carbon Monoxide Gas (250 ppm)"}}, {"GSM406487": {"TREATMENT": "Carbon Monoxide Gas (250 ppm)"}}, {"GSM406487": {"TREATMENT": "Carbon Monoxide Gas (250 ppm)"}}, {"GSM406487": {"TREATMENT": "Carbon Monoxide Gas (250 ppm)"}}, {"GSM406492": {"TREATMENT": "LPS (1 ug/ml) and Carbon Monoxide (250 ppm)"}}, {"GSM406492": {"TREATMENT": "LPS (1 ug/ml) and Carbon Monoxide (250 ppm)"}}, {"GSM406492": {"TREATMENT": "LPS (1 ug/ml) and Carbon Monoxide (250 ppm)"}}, {"GSM406492": {"TREATMENT": "LPS (1 ug/ml) and Carbon Monoxide (250 ppm)"}}, {"GSM406492": {"TREATMENT": "LPS (1 ug/ml) and Carbon Monoxide (250 ppm)"}}, {"GSM406497": {"TREATMENT": "LPS (1 ug/ml) and Air"}}, {"GSM406497": {"TREATMENT": "LPS (1 ug/ml) and Air"}}, {"GSM406497": {"TREATMENT": "LPS (1 ug/ml) and Air"}}, {"GSM406497": {"TREATMENT": "LPS (1 ug/ml) and Air"}}, {"GSM406497": {"TREATMENT": "LPS (1 ug/ml) and Air"}}], "id": 3289, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "This study investigated the global effect of carbon monoxide (CO) gas (250 ppm) on LPS- induced gene expression in THP-1 cells. CO...", "geo_gse_id": "E-GEOD-16193", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 20, "tags": ["cell", "gas", "line"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "interfering-with-proximal-tlr4-to-nf-kappab-signal", "geo_id_plat": "E-GEOD-16193_A-AFFY-44", "name": "Interfering with Proximal TLR4 to NF-kappaB Signal Transduction in Human Monocytes", "created": "Sep.12, 2014", "summary": "This study investigated the global effect of carbon monoxide (CO) gas (250 ppm) on LPS- induced gene expression in THP-1 cells. CO predominantly suppresses LPS-induced gene response. Of the CO-suppressed genes, 18% were transcription factors and most others were cytokines, chemokines and immune response genes. Sequence analysis B binding siteskappafound that 81% of the gene promoters have putative NF- These results suggest that CO inhibits LPS-induced inflammatory B signaling pathwayresponse through regulating NF- The microarrays were performed on THP-1 cells, a human monocytic cell line. Cells were treated with or without LPS (1 \u00b5g/ml) in presence or absence of carbon monoxide (250 ppm) for 1 h. Total RNA was isolated, reverse transcribed, labeled and hybridized to oligonucleotide microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16193", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16193/samples/"}