{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3287, "factors": [{"GSM799168": {"CELL LINE": "BT474", "LAPATINIB SENSITIVITY": "lapatinib-sensitive", "TREATMENT": "DMSO"}}, {"GSM799168": {"CELL LINE": "BT474", "LAPATINIB SENSITIVITY": "lapatinib-sensitive", "TREATMENT": "DMSO"}}, {"GSM799168": {"CELL LINE": "BT474", "LAPATINIB SENSITIVITY": "lapatinib-sensitive", "TREATMENT": "DMSO"}}, {"GSM79917": {"CELL LINE": "BT474", "LAPATINIB SENSITIVITY": "lapatinib-sensitive", "TREATMENT": "lapatinib"}}, {"GSM79917": {"CELL LINE": "BT474", "LAPATINIB SENSITIVITY": "lapatinib-sensitive", "TREATMENT": "lapatinib"}}, {"GSM79917": {"CELL LINE": "BT474", "LAPATINIB SENSITIVITY": "lapatinib-sensitive", "TREATMENT": "lapatinib"}}, {"GSM799174": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "DMSO"}}, {"GSM799174": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "DMSO"}}, {"GSM799174": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "DMSO"}}, {"GSM799177": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "foretinib"}}, {"GSM799177": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "foretinib"}}, {"GSM799177": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "foretinib"}}, {"GSM799180": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "lapatinib"}}, {"GSM799180": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "lapatinib"}}, {"GSM799180": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "lapatinib"}}, {"GSM799183": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "lapatinib and foretinib"}}, {"GSM799183": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "lapatinib and foretinib"}}, {"GSM799183": {"CELL LINE": "BT474-J4", "LAPATINIB SENSITIVITY": "acquired lapatinib-resistant", "TREATMENT": "lapatinib and foretinib"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "These data provide scientific information to understand the mechanism of action of lapatinib resistance in HER2-positive patients and to...", "pubmed_id": 19671800, "geo_gse_id": "E-GEOD-16179", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 18, "tags": ["cell", "line"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "bt474-and-bt474-j4-microarray-data", "geo_id_plat": "E-GEOD-16179_A-AFFY-44", "name": "BT474 and BT474-J4 microarray data", "created": "Sep.12, 2014", "summary": "These data provide scientific information to understand the mechanism of action of lapatinib resistance in HER2-positive patients and to test the combination of HER2-targeted agents and GSK1363089 (foretinib) in the clinic by using an acquired lapatinib-resistant cell line. Cell lines (BT474, an HER2-positive and lapatinib-sensitive cell line; BT474-J4, an acquired lapatinib-resistant cell line) were treated with lapatinib alone (1uM), foretinib (GSK1363089) alone (0.1 uM), a combination of lapatinib (1 uM) and foretinib (0.1 uM), or DMSO control for 24 hours. Triplicates were performed.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16179", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16179/samples/"}