ArrayExpress Uploader0328621 3/7euploidfemale21 4/7Down syndromefemale17 5/7euploidfemale17 2/7Down syndromefemale17 2/7euploidmale17 1/7Down syndromemale18 2/7euploidmale19 5/7Down syndromemale20 4/7euploidmale21 1/7Down syndromemale17euploidmale16 4/7Down syndromemale18 1/7euploidmale19 6/7Down syndromemalearrayexpress_sid4In order to characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we compared gene expression in...19474297E-GEOD-16176/profile/8773/arrayexpressuploader314chromosomedown syndromeproteinsyndromeDec.12, 2014Falseexpression-profiles-of-amniotic-fluid-from-human-fE-GEOD-16176_A-AFFY-44Expression profiles of amniotic fluid from human fetuses with Down syndrome and euploid controlsSep.12, 2014In order to characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we compared gene expression in uncultured amniotic fluid supernatant samples. We identified individually differentially expressed genes via paired t-tests in the matched samples, and a set of differentially expressed genes on chromosome 21 using Gene Set Enrichment Analysis. Functional pathway analysis of the resulting genes highlighted the importance of oxidative stress, ion transport, and G-protein signaling in the DS fetuses. We profiled seven DS expression samples and seven controls matched for gender and approximate gestational age..http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16176humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16176/samples/