ArrayExpress Uploader03285Patient 0002atopic dermatitis (AD)Patient 0004atopic dermatitis (AD)Patient 0005atopic dermatitis (AD)Patient 0006atopic dermatitis (AD)Patient 0007atopic dermatitis (AD)Patient 0008atopic dermatitis (AD)Patient 0009atopic dermatitis (AD)Patient 0010atopic dermatitis (AD)Patient 0011atopic dermatitis (AD)Patient 1normalPatient 2normalPatient 3normalPatient 4normalPatient 5normalPatient 6normalPatient 7normalPatient 8normalPatient 10normalarrayexpress_sid4In this study we used genomic profiling to characterize differences in expression of genes related to epidermal growth/differentiation...20004782E-GEOD-16161/profile/8773/arrayexpressuploader218atopic dermatitisdendriticdermatitispsoriasisskinDec.12, 2014FalseE-GEOD-16161_A-AFFY-44broad-defects-in-epidermal-cornification-in-atopicBroad defects in epidermal cornification in atopic dermatitis (AD) identified through genomic analysisSep.12, 2014In this study we used genomic profiling to characterize differences in expression of genes related to epidermal growth/differentiation and inflammatory circuits in skin lesions of psoriasis and atopic dermatitis (AD), comparing expression values to normal skin. Skin biopsies were collected from 9 patients with chronic atopic dermatitis, 15 psoriasis patients, and 9 healthy volunteers. Keywords: Genetic-pathology Psoriasis and AD are common inflammatory skin diseases which share important features, including: 1) large infiltrates of T-cells and inflammatory dendritic cells in skin lesions, 2) immune activation with up-regulated expression of many cytokines, chemokines, and inflammatory molecules 3) marked epidermal hyperplasia in chronic diseased skin and 4) defective barrier function with increased transepidermal water loss (TEWL), which reflects underlying alterations in keratinocyte differentiation. Using genomic profiling we provide a comprehensive comparison of chronic psoriasis and AD skin lesions as compared with normal skin.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16161humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16161/samples/