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status: deadSLN:1884Follow up status: aliveSLN:1885Follow up status: deadSLN:1887Follow up status: aliveSLN:1888Follow up status: deadSLN:1890Follow up status: deadSLN:1894Follow up status: aliveSLN:1896Follow up status: aliveSLN:1897Follow up status: aliveSLN:1898Follow up status: aliveSLN:1900Follow up status: aliveSLN:1904Follow up status: deadSLN:1905Follow up status: deadSLN:1906Follow up status: deadSLN:1907Follow up status: aliveSLN:1910Follow up status: deadSLN:1912Follow up status: aliveSLN:1913Follow up status: aliveSLN:1916Follow up status: deadSLN:1918Follow up status: deadSLN:1919Follow up status: deadSLN:1841Follow up status: deadSLN:1857arrayexpress_sid3Follicular lymphoma (FL) is genetically characterized by the presence of the t(14;18)(q32;q21) chromosomal translocation in approximately...19471018E-GEOD-16131/profile/8773/arrayexpressuploader0184cellfollicular lymphomalymphomaJan.17, 2015Falsedifferences-between-follicular-lymphoma-with-and-wE-GEOD-16131_A-AFFY-33Differences Between Follicular Lymphoma With and Without Translocation t(14;18)Jan.17, 2015Follicular lymphoma (FL) is genetically characterized by the presence of the t(14;18)(q32;q21) chromosomal translocation in approximately 90% of cases. In contrast to FL carrying the t(14;18), their t(14;18)-negative counterparts are less well studied regarding their immunohistochemical, genetic, molecular and clinical features. Within a previously published series of 184 FL grade 1-3A with available gene expression data, we identified 17 FL lacking the t(14;18). Comparative genomic hybridization and high resolution SNP array profiling demonstrated that gains/amplifications of the BCL2 gene locus in 18q were restricted to the t(14;18)-positive FL subgroup. A comparison of gene expression profiles revealed an enrichment of germinal center B-cell associated signatures in t(14;18)-positive FL, whereas activated B-cell like, NFƒÛB, proliferation and bystander cell signatures were enriched in t(14;18)-negative FL. These findings were confirmed by immunohistochemistry in an independent validation series of 84 FL, in which 32% of t(14;18)-negative FL showed weak or absent CD10 expression and 91% an increased Ki67 proliferation rate. Although overall survival did not differ between FL with and without t(14;18), our findings suggest distinct molecular features of t(14;18)-negative FL. Fresh-frozen tumor-biopsy specimens were obtained from 184 untreated patients who had received a diagnosis of follicular lymphoma. RNA was extracted from the biopsy specimens and was examined for gene expression with the use of Affymetrix U133A and U133B microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16131humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16131/samples/