ArrayExpress Uploaderarrayexpress_sidhuman326404Cyclophilin binding drugs, NIM811 and cyclosporin A (CsA), inhibit the replication of HCV replicon. We investigated the mode of action of...E-GEOD-15935/profile/8773/arrayexpressuploader082cellDec.12, 2014FalseE-GEOD-15935_A-AFFY-44transcription-profiling-of-human-naive-and-hvc-repTranscription profiling of human naive and HVC-replicon containing Huh7 cells were treated with CsA or NIM811 to investigate mode of action of these drugs and identified host factors essential for HCV replication in a subgenomic replicon model.Sep.12, 2014Cyclophilin binding drugs, NIM811 and cyclosporin A (CsA), inhibit the replication of HCV replicon. We investigated the mode of action of these drugs and identified host factors essential for HCV replication in a subgenomic replicon model. Experiment Overall Design: Cultured Huh7 cell were treated with CsA or NIM811 at different concentrations. Cells were harvested after 12, 24 or 48 hours. The extracted mRNA were hybridized on Affymetrix U133 Plus 2 microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15935http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15935/samples/