ArrayExpress Uploader09687Ewing tumornot specifiedEwing tumornot specifiedEwing tumornot specifiedEwing tumornot specifiedneuroblastomaIVneuroblastomaIneuroblastomaIIIneuroblastomaIneuroblastomaIIIarrayexpress_sid3We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem...19502792E-GEOD-15757/profile/8773/arrayexpressuploader09cellcentralneuroblastomaJan.17, 2015Falseprc2-in-ewing-tumorsE-GEOD-15757_A-AFFY-33PRC2 in Ewing tumorsJan.17, 2015We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem cells (Richter GH et al., Proc Natl Acad Sci U S A. 2009;106:5324-9). Downregulation of EZH2 by RNA interference in Ewing tumor cell lines suppressed oncogenic transformation in vitro and in vivo. These data suggest that EZH2 might play a central role in Ewing Tumor pathology. RNA from tumor samples was isolated with Trizol and subjected to microarray analysis using HG_U133A microarrays following the Affymetrix protocol. Ewing tumors vs. neuroblastoma controlshttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15757humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15757/samples/