{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 9687, "factors": [{"GSM395600 1": {"TUMOR TYPE": "Ewing tumor", "STAGE": "not specified"}}, {"GSM395601 1": {"TUMOR TYPE": "Ewing tumor", "STAGE": "not specified"}}, {"GSM395602 1": {"TUMOR TYPE": "Ewing tumor", "STAGE": "not specified"}}, {"GSM395603 1": {"TUMOR TYPE": "Ewing tumor", "STAGE": "not specified"}}, {"GSM398822 1": {"TUMOR TYPE": "neuroblastoma", "STAGE": "IV"}}, {"GSM398823 1": {"TUMOR TYPE": "neuroblastoma", "STAGE": "I"}}, {"GSM398824 1": {"TUMOR TYPE": "neuroblastoma", "STAGE": "III"}}, {"GSM398825 1": {"TUMOR TYPE": "neuroblastoma", "STAGE": "I"}}, {"GSM398826 1": {"TUMOR TYPE": "neuroblastoma", "STAGE": "III"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 3, "summary_wrapped": "We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem...", "pubmed_id": 19502792, "geo_gse_id": "E-GEOD-15757", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 9, "tags": ["cell", "central", "neuroblastoma"], "lastmodified": "Jan.17, 2015", "is_default": false, "geo_gds_id": "", "slug": "prc2-in-ewing-tumors", "geo_id_plat": "E-GEOD-15757_A-AFFY-33", "name": "PRC2 in Ewing tumors", "created": "Jan.17, 2015", "summary": "We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem cells (Richter GH et al., Proc Natl Acad Sci U S A. 2009;106:5324-9). Downregulation of EZH2 by RNA interference in Ewing tumor cell lines suppressed oncogenic transformation in vitro and in vivo. These data suggest that EZH2 might play a central role in Ewing Tumor pathology. RNA from tumor samples was isolated with Trizol and subjected to microarray analysis using HG_U133A microarrays following the Affymetrix protocol. Ewing tumors vs. neuroblastoma controls", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15757", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15757/samples/"}