{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSE15624GSM391214": {}}, {"GSE15624GSM391215": {}}, {"GSE15624GSM391216": {}}, {"GSE15624GSM391217": {}}, {"GSE15624GSM391218": {}}, {"GSE15624GSM391219": {}}, {"GSE15624GSM391220": {}}, {"GSE15624GSM391221": {}}, {"GSE15624GSM391222": {}}, {"GSE15624GSM391223": {}}, {"GSE15624GSM391224": {}}, {"GSE15624GSM391225": {}}], "id": 5667, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "T cell differentiation to the Th17 effector subset requires stimulation through the T cell and co-stimulatory receptors, together with...", "geo_gse_id": "E-GEOD-15624", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 12, "tags": ["amino acid", "cell", "cytokine"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-mouse-t-cells-treated-w", "geo_id_plat": "E-GEOD-15624_A-AFFY-45", "name": "Transcription profiling of mouse T cells treated with halofuginone to investigate regulation of Y cell gene expression by Halofuginone (HF)", "created": "Nov.11, 2014", "summary": "T cell differentiation to the Th17 effector subset requires stimulation through the T cell and co-stimulatory receptors, together with cytokine stimulation by TGFb and IL-6. The small molecule halofuginone (HF) inhibits Th17 cell development and induces a pattern of stress-regulated gene expression that mimics amino acid starvation. We used global transcript profiling to ask how halofuginone modulates gene expression induced during T cell activaiton and Th17 differentiation Experiment Overall Design: Purified mouse CD4+ CD25- T cells were activated under Th17 polarizing cytokine conditions and treated with either halofuginone or its inactive derivative, MAZ1310, for 3- or 6-hours.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15624", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15624/samples/"}