ArrayExpress Uploader0mouse28FGFR3 and FGFR4 double heterozygous mutant28FGFR3 and FGFR4 double heterozygous mutant28FGFR3 and FGFR4 double heterozygous mutant28FGFR3 and FGFR4 double knockout28FGFR3 and FGFR4 double knockout28FGFR3 and FGFR4 double knockout28wild type genotype28wild type genotype1FGFR3 and FGFR4 double heterozygous mutant1FGFR3 and FGFR4 double heterozygous mutant1FGFR3 and FGFR4 double heterozygous mutant1FGFR3 and FGFR4 double knockout1FGFR3 and FGFR4 double knockout1FGFR3 and FGFR4 double knockout1wild type genotype1wild type genotype1wild type genotype8FGFR3 and FGFR4 double heterozygous mutant8FGFR3 and FGFR4 double heterozygous mutant8FGFR3 and FGFR4 double heterozygous mutant8FGFR3 and FGFR4 double knockout8FGFR3 and FGFR4 double knockout8FGFR3 and FGFR4 double knockout8wild type genotype8wild type genotype8wild type genotype5658arrayexpress_sid6Gene expression profiling of newborn lung tissue revealed few changes in compound FGFR3/FGFR4 deficient mice, consistent with their...20093646/profile/8773/arrayexpressuploader226elastic fiberfiberlungDec.12, 2014FalseE-GEOD-15452_A-AFFY-45expression-data-from-lung-of-mice-bearing-mutationhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15452Expression data from lung of mice bearing mutations of FGFR3 and FGFR4Nov.11, 2014Gene expression profiling of newborn lung tissue revealed few changes in compound FGFR3/FGFR4 deficient mice, consistent with their normal lung morphology at birth, suggesting the sequence of events leading to the phenotype initiates after birth in this model. Profiling of 4 week-old lung tissues revealed an induction of genes related to elastic fiber assembly in compound mutants. Lung RNA isolated from three animals of each genotype-age group were pooled for each Affymetrix chip (n=3 chips for each, except n=2 for wild type at 4 weeks.E-GEOD-15452http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15452/samples/