{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3224, "factors": [{"GSM38572": {"CELL LINE": "parental A2780"}}, {"GSM38572": {"CELL LINE": "parental A2780"}}, {"GSM38572": {"CELL LINE": "parental A2780"}}, {"GSM38572": {"CELL LINE": "parental A2780"}}, {"GSM38572": {"CELL LINE": "parental A2780"}}, {"GSM385726": {"CELL LINE": "Round5 A2780"}}, {"GSM385726": {"CELL LINE": "Round5 A2780"}}, {"GSM385726": {"CELL LINE": "Round5 A2780"}}, {"GSM385726": {"CELL LINE": "Round5 A2780"}}, {"GSM385726": {"CELL LINE": "Round5 A2780"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these...", "pubmed_id": 19505326, "geo_gse_id": "E-GEOD-15372", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 10, "tags": ["cancer", "cell", "line", "ovarian cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-a2780-cisplatin-sensitive-and", "geo_id_plat": "E-GEOD-15372_A-AFFY-44", "name": "Expression data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines.", "created": "Sep.12, 2014", "summary": "Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, subsequently resulting in a poor long-term prognosis.  To model the onset of drug resistance, we measured gene expression alterations associated with cisplatin resistance. We treated clonally derived, drug-sensitive A2780 epithelial ovarian cancer cells with increasing concentrations of cisplatin.  After 5 cycles of drug selection, the isogenic drug-sensitive (parental A2780) and -resistant (Round5 A2780) cell lines were subjected to mRNA expression microarray analyses.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15372", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15372/samples/"}