{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM406203 1": {"CELL TYPE": "CD2- plasmacytoid dendritic cell"}}, {"GSM406204 1": {"CELL TYPE": "CD2- plasmacytoid dendritic cell"}}, {"GSM406205 1": {"CELL TYPE": "CD2+ plasmacytoid dendritic cell"}}, {"GSM406206 1": {"CELL TYPE": "CD2+ plasmacytoid dendritic cell"}}], "id": 9640, "pop_total": 0, "platform": 3, "summary_wrapped": "Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral...", "pubmed_id": 19454677, "geo_gse_id": "E-GEOD-15215", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 4, "tags": ["cancer", "cell", "dendritic"], "lastmodified": "Jan.17, 2015", "is_default": false, "geo_id_plat": "E-GEOD-15215_A-AFFY-33", "slug": "cd2-distinguishes-two-subsets-of-human-plasmacytoi", "geo_gds_id": "", "name": "CD2 distinguishes two subsets of human plasmacytoid  dendritic cells with distinct phenotype and functions", "created": "Jan.17, 2015", "summary": "Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion. Expression of CD2 distinguishes two pDC subsets with distinct phenotype and function. Both subsets secrete IFN-alpha and express Granzyme B and TRAIL. CD2high pDCs uniquely express lysozyme and can be found in tonsils and in tumors. Both subsets launch recall T cell response. However, CD2high pDCs secrete higher levels of IL12 p40, express higher levels of co-stimulatory molecule CD80 and are more efficient in triggering proliferation of na\u00efve allogeneic T cells. Thus, human blood pDCs are composed of subsets with specific phenotype and functions. pDC subsets were isolated from two different donors. They were analyzed in two independent experiments.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15215", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-15215/samples/"}