{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3178, "factors": [{"GSE14905GSM372286": {}}, {"GSE14905GSM372287": {}}, {"GSE14905GSM372288": {}}, {"GSE14905GSM372289": {}}, {"GSE14905GSM372290": {}}, {"GSE14905GSM372291": {}}, {"GSE14905GSM372292": {}}, {"GSE14905GSM372293": {}}, {"GSE14905GSM372294": {}}, {"GSE14905GSM372295": {}}, {"GSE14905GSM372296": {}}, {"GSE14905GSM372297": {}}, {"GSE14905GSM372298": {}}, {"GSE14905GSM372299": {}}, {"GSE14905GSM372300": {}}, {"GSE14905GSM372301": {}}, {"GSE14905GSM372302": {}}, {"GSE14905GSM372303": {}}, {"GSE14905GSM372304": {}}, {"GSE14905GSM372305": {}}, {"GSE14905GSM372306": {}}, {"GSE14905GSM372307": {}}, {"GSE14905GSM372308": {}}, {"GSE14905GSM372309": {}}, {"GSE14905GSM372310": {}}, {"GSE14905GSM372311": {}}, {"GSE14905GSM372312": {}}, {"GSE14905GSM372313": {}}, {"GSE14905GSM372314": {}}, {"GSE14905GSM372315": {}}, {"GSE14905GSM372316": {}}, {"GSE14905GSM372317": {}}, {"GSE14905GSM372318": {}}, {"GSE14905GSM372319": {}}, {"GSE14905GSM372320": {}}, {"GSE14905GSM372321": {}}, {"GSE14905GSM372322": {}}, {"GSE14905GSM372323": {}}, {"GSE14905GSM372324": {}}, {"GSE14905GSM372325": {}}, {"GSE14905GSM372326": {}}, {"GSE14905GSM372327": {}}, {"GSE14905GSM372328": {}}, {"GSE14905GSM372329": {}}, {"GSE14905GSM372330": {}}, {"GSE14905GSM372331": {}}, {"GSE14905GSM372332": {}}, {"GSE14905GSM372333": {}}, {"GSE14905GSM372334": {}}, {"GSE14905GSM372335": {}}, {"GSE14905GSM372336": {}}, {"GSE14905GSM372337": {}}, {"GSE14905GSM372338": {}}, {"GSE14905GSM372339": {}}, {"GSE14905GSM372340": {}}, {"GSE14905GSM372341": {}}, {"GSE14905GSM372342": {}}, {"GSE14905GSM372343": {}}, {"GSE14905GSM372344": {}}, {"GSE14905GSM372345": {}}, {"GSE14905GSM372346": {}}, {"GSE14905GSM372347": {}}, {"GSE14905GSM372348": {}}, {"GSE14905GSM372349": {}}, {"GSE14905GSM372350": {}}, {"GSE14905GSM372351": {}}, {"GSE14905GSM372352": {}}, {"GSE14905GSM372353": {}}, {"GSE14905GSM372354": {}}, {"GSE14905GSM372355": {}}, {"GSE14905GSM372356": {}}, {"GSE14905GSM372357": {}}, {"GSE14905GSM372358": {}}, {"GSE14905GSM372359": {}}, {"GSE14905GSM372360": {}}, {"GSE14905GSM372361": {}}, {"GSE14905GSM372362": {}}, {"GSE14905GSM372363": {}}, {"GSE14905GSM372364": {}}, {"GSE14905GSM372365": {}}, {"GSE14905GSM372366": {}}, {"GSE14905GSM372367": {}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "We observed robust overexpression of type I interferon (IFN)\u2013inducible genes and genomic signatures that indicate T cell and dendritic...", "pubmed_id": 18648529, "geo_gse_id": "E-GEOD-14905", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 82, "tags": ["cell", "dendritic", "disease", "psoriasis", "skin"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-human-psoriasis-patient", "geo_id_plat": "E-GEOD-14905_A-AFFY-44", "name": "Transcription profiling of human psoriasis patient matched lesion and normal tissue vs. normal controls - type i interferon: potential therapeutic target for psoriasis?", "created": "Sep.12, 2014", "summary": "We observed robust overexpression of type I interferon (IFN)\u2013inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN\u2013inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. Concordant overexpression of IFN-c and TNF-a\u2013inducible gene signatures occurred at the same disease sites. Experiment Overall Design: A total of 82 Affymetrix HGU133 Plus arrays were run on 54 total subjects. This includes: skin biopsy samples from 21 normal healthy donors (Normal-1 to Normal-21), 56 skin biopsy samples from 28 psoriasis patients who had match lesional and uninvolved (non-lesional) tissue (NS-1/LS-1 to NS-9/LS-9,  NS-11/LS-11 to NS-14/LS-14, and NS-16/LS-16 to NS-30/LS-30), and 5 samples from psoriasis patients that only provided lesional skin biopsies (LS-10, LS-15, and LS-31 to LS-33).", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14905", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14905/samples/"}