ArrayExpress Uploader03174lung squamous BEAS-2B Control cellslung squamous BEAS-2B SOX2 cellsarrayexpress_sid4We have identified SOX2 as a new oncogene and a likely driver of recurrent 3q26.3 amplifications in lung Squamous Cell Carcinoma. SOX2...20126410E-GEOD-14883/profile/8773/arrayexpressuploader12carcinomacelllunglung squamous cell carcinomasquamoussquamous cellsquamous cell carcinomaDec.12, 2014Falsesox2-overexpression-effect-on-human-lung-squamousE-GEOD-14883_A-AFFY-44SOX2 overexpression effect on human lung squamous cellsSep.12, 2014We have identified SOX2 as a new oncogene and a likely driver of recurrent 3q26.3 amplifications in lung Squamous Cell Carcinoma. SOX2 is a crucial transcription factor implicated in Embryonic and Neural Stem Cells, that we found widely activatd in human lung SCC. This part of the study aimed at analyzing the transcriptomic consequences of SOX2 overexpression in a simple in vitro model (human lung squamous immortalized cells). Human lung squamous BEAS-2B cells were transduced for Control or SOX2 expression, and their transcriptomes compared using Affymetrix arrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14883humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14883/samples/