Dataset: Transcription profiling of human rhabdomyosarcoma cells expressing Myod and E-protein heterodimer and controls

Rhabdomyosarcomas (RMS) are characterized by expression of myogenic specification genes, such as MyoD and/or Myf5, as well as their bHLH partners for heterodimerization, the E-proteins. We have shown that expression of a forced heterodimer of MyoD with one of the E2A proteins, E12, leads to differentiation in a RMS cell culture model when exposed to low serum conditions. Experiment Overall Design: RD cells (a type of RMS) were retrovirally infected with either the MyoD~E heterodimer or an empty control vector, differentiated for 24 hours and then RNA collected.

Species:

human

Samples:

6

Source:

E-GEOD-14825

Updated:

Dec.12, 2014

Registered:

Sep.11, 2014