{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSE14769GSM368811": {}}, {"GSE14769GSM368812": {}}, {"GSE14769GSM368813": {}}, {"GSE14769GSM368814": {}}, {"GSE14769GSM368815": {}}, {"GSE14769GSM368816": {}}, {"GSE14769GSM368817": {}}, {"GSE14769GSM368818": {}}, {"GSE14769GSM368819": {}}, {"GSE14769GSM368820": {}}, {"GSE14769GSM368821": {}}, {"GSE14769GSM368822": {}}, {"GSE14769GSM368823": {}}, {"GSE14769GSM368824": {}}, {"GSE14769GSM368825": {}}, {"GSE14769GSM368826": {}}, {"GSE14769GSM368827": {}}, {"GSE14769GSM368828": {}}, {"GSE14769GSM368829": {}}, {"GSE14769GSM368830": {}}, {"GSE14769GSM368831": {}}, {"GSE14769GSM368832": {}}, {"GSE14769GSM368833": {}}, {"GSE14769GSM368834": {}}], "id": 5621, "pop_total": 0, "platform": 6, "summary_wrapped": "The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can...", "pubmed_id": 19270711, "geo_gse_id": "E-GEOD-14769", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 24, "tags": ["bone", "bone marrow", "immune system", "left"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-14769_A-AFFY-45", "slug": "transcription-profiling-of-mouse-bone-marrow-der-2", "geo_gds_id": "", "name": "Transcription profiling of mouse bone marrow-derived macrophages simulated with LPS, time series", "created": "Nov.10, 2014", "summary": "The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases.  Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interplay between the transcription factors NF-\u03baB, C/EBP\u03b4, and ATF3 that controls inflammatory responses.  We mathematically modeled transcriptional regulation of Il6 and Cebpd genes and experimentally validated the prediction that the combination of an initiator (NF-\u03baB), an amplifier (C/EBP\u03b4) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately. Experiment Overall Design: Bone marrow-derived macrophages stimulated with LPS for 0, 20, 40, 60, 80, 120, 240 and 360 minutes.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14769", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14769/samples/"}