{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSE14499GSM362115": {}}, {"GSE14499GSM362116": {}}, {"GSE14499GSM362117": {}}, {"GSE14499GSM362118": {}}, {"GSE14499GSM362119": {}}, {"GSE14499GSM362120": {}}, {"GSE14499GSM362121": {}}, {"GSE14499GSM362122": {}}, {"GSE14499GSM362123": {}}, {"GSE14499GSM362124": {}}, {"GSE14499GSM362125": {}}, {"GSE14499GSM362126": {}}, {"GSE14499GSM362127": {}}, {"GSE14499GSM362128": {}}, {"GSE14499GSM362129": {}}, {"GSE14499GSM362130": {}}, {"GSE14499GSM362131": {}}, {"GSE14499GSM362132": {}}, {"GSE14499GSM362133": {}}, {"GSE14499GSM362134": {}}, {"GSE14499GSM362135": {}}, {"GSE14499GSM362136": {}}, {"GSE14499GSM362137": {}}, {"GSE14499GSM362138": {}}, {"GSE14499GSM362139": {}}, {"GSE14499GSM362140": {}}], "id": 5608, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "We examined transgenic (TG) mice expressing human APP695 bearing the double Swedish (671KM>NL) and Indiana (717V>F) amyloid precursor...", "geo_gse_id": "E-GEOD-14499", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 26, "tags": ["actin", "cell", "cortex", "hippocampus", "point", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-mouse-app-transgenic-mo", "geo_id_plat": "E-GEOD-14499_A-AFFY-45", "name": "Transcription profiling of mouse APP transgenic mouse model of Alzheimers disease treated with BDNF", "created": "Nov.10, 2014", "summary": "We examined transgenic (TG) mice expressing human APP695 bearing the double Swedish (671KM>NL) and Indiana (717V>F) amyloid precursor protein (APP) mutations. Lentiviral vectors constitutively expressing BDNF-GFP under control of the CMV/\u00df-actin hybrid promoter or GFP alone were injected into the entorhinal cortices of TG mice bilaterally at age 6 months, a time point by which neuropathological degeneration and cell loss are established. Age-matched wild-type littermates underwent sham surgery or injection of lentivirus expressing GFP into the entorhinal cortices bilaterally. Experiment Overall Design: 26 Samples total: 4 biological replicates of APP transgenic mice BDNF treated, 4 biological replicates of APP transgenic mice GFP treated, 3 biological replicates of non-trangenic mice sham lesion and 2 biological replicates of non-transgenic mice GFP treated for both tissues: Entorhinal cortex and hippocampus.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14499", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14499/samples/"}