{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 8233, "factors": [{"GSM361017": {"SAMPLE": "SZ32", "SEX": "M"}}, {"GSM361018": {"SAMPLE": "SZ20", "SEX": "M"}}, {"GSM361019": {"SAMPLE": "SZ26", "SEX": "M"}}, {"GSM361020": {"SAMPLE": "SZ33", "SEX": "M"}}, {"GSM36102": {"SAMPLE": "SZ27", "SEX": "M"}}, {"GSM361022": {"SAMPLE": "SZ19", "SEX": "M"}}, {"GSM361023": {"SAMPLE": "SZ21", "SEX": "M"}}, {"GSM361024": {"SAMPLE": "SZ23", "SEX": "M"}}, {"GSM361025": {"SAMPLE": "SZ25", "SEX": "M"}}, {"GSM361026": {"SAMPLE": "SZ14", "SEX": "M"}}, {"GSM361027": {"SAMPLE": "SZ15", "SEX": "F"}}, {"GSM361028": {"SAMPLE": "SZ17", "SEX": "M"}}, {"GSM361029": {"SAMPLE": "SZ22", "SEX": "M"}}, {"GSM361030": {"SAMPLE": "SZ31", "SEX": "M"}}, {"GSM36103": {"SAMPLE": "SZ18", "SEX": "M"}}, {"GSM361032": {"SAMPLE": "SZ24", "SEX": "M"}}], "pop_total": 0, "platform": 7, "summary_wrapped": "The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors...", "pubmed_id": 19404390, "geo_gse_id": "E-GEOD-14449", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 16, "tags": ["adenocarcinoma", "disease", "liquid", "lung", "lung adenocarcinoma", "nsclc"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-14449_A-AFFY-23", "slug": "gene-expression-profiles-of-spontaneous-metastasis", "geo_gds_id": "", "name": "Gene expression profiles of spontaneous metastasis in a K-ras/p53 mutant mouse model", "created": "Nov.23, 2014", "summary": "The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature. Primary lung adenocarcinomas and metastases from p53R172H\u2206g/+ K-rasLA1/+ mice or syngeneic tumors were isolated, carefully dissected to remove the adjacent tissue, snap-frozen in liquid nitrogen and stored at -80\u00b0 until use. Part of each dissected tumor was histologically evaluated by a board-certified pathologist.  Synthesis of cRNA and hybridization to Mouse Expression Array 430A 2.0 chips were performed.  Two-sided t-paired tests using log-transformed expression values determined significant differences between primary tumors and metastasis.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14449", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14449/samples/"}